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2l4r

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{{Seed}}
 
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[[Image:2l4r.jpg|left|200px]]
 
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==NMR solution structure of the N-terminal PAS domain of hERG==
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The line below this paragraph, containing "STRUCTURE_2l4r", creates the "Structure Box" on the page.
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<StructureSection load='2l4r' size='340' side='right'caption='[[2l4r]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2l4r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L4R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L4R FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l4r OCA], [https://pdbe.org/2l4r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l4r RCSB], [https://www.ebi.ac.uk/pdbsum/2l4r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l4r ProSAT]</span></td></tr>
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{{STRUCTURE_2l4r| PDB=2l4r | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/KCNH2_HUMAN KCNH2_HUMAN] Defects in KCNH2 are the cause of long QT syndrome type 2 (LQT2) [MIM:[https://omim.org/entry/613688 613688]. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress. Deafness is often associated with LQT2.<ref>PMID:16361248</ref> <ref>PMID:9600240</ref> <ref>PMID:7889573</ref> <ref>PMID:8914737</ref> <ref>PMID:8635257</ref> <ref>PMID:8877771</ref> <ref>PMID:9024139</ref> <ref>PMID:9693036</ref> <ref>PMID:9544837</ref> <ref>PMID:9452080</ref> <ref>PMID:10086971</ref> <ref>PMID:10220144</ref> <ref>PMID:10187793</ref> <ref>PMID:10517660</ref> <ref>PMID:10735633</ref> <ref>PMID:10973849</ref> <ref>PMID:10862094</ref> <ref>PMID:10753933</ref> <ref>PMID:12062363</ref> <ref>PMID:12354768</ref> <ref>PMID:12621127</ref> <ref>PMID:15051636</ref> <ref>PMID:15840476</ref> <ref>PMID:22314138</ref> Defects in KCNH2 are the cause of short QT syndrome type 1 (SQT1) [MIM:[https://omim.org/entry/609620 609620]. Short QT syndromes are heart disorders characterized by idiopathic persistently and uniformly short QT interval on ECG in the absence of structural heart disease in affected individuals. They cause syncope and sudden death.<ref>PMID:14676148</ref> <ref>PMID:15828882</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/KCNH2_HUMAN KCNH2_HUMAN] Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
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===NMR solution structure of the N-terminal PAS domain of hERG===
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==See Also==
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*[[Potassium channel 3D structures|Potassium channel 3D structures]]
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== References ==
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21055387 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21055387}}
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==About this Structure==
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2L4R is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L4R OCA].
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==Reference==
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<ref group="xtra">PMID:21055387</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chen, A S.]]
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[[Category: Large Structures]]
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[[Category: Gayen, N.]]
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[[Category: Chen AS]]
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[[Category: Huang, Q.]]
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[[Category: Gayen N]]
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[[Category: Kang, C.]]
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[[Category: Huang Q]]
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[[Category: Li, Q.]]
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[[Category: Kang C]]
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[[Category: Raida, M.]]
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[[Category: Li Q]]
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[[Category: Eag domain]]
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[[Category: Raida M]]
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[[Category: Herg]]
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[[Category: Pas domain]]
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[[Category: Potassium channel]]
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[[Category: Transport protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 22 09:49:45 2010''
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Current revision

NMR solution structure of the N-terminal PAS domain of hERG

PDB ID 2l4r

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