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2l66

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==The DNA-recognition fold of Sso7c4 suggests a new member of SpoVT-AbrB superfamily from archaea.==
==The DNA-recognition fold of Sso7c4 suggests a new member of SpoVT-AbrB superfamily from archaea.==
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<StructureSection load='2l66' size='340' side='right' caption='[[2l66]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
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<StructureSection load='2l66' size='340' side='right'caption='[[2l66]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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[[2l66]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L66 OCA]. <br>
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<table><tr><td colspan='2'>[[2l66]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus_98/2 Saccharolobus solfataricus 98/2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L66 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L66 FirstGlance]. <br>
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<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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== Publication Abstract from PubMed ==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l66 OCA], [https://pdbe.org/2l66 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l66 RCSB], [https://www.ebi.ac.uk/pdbsum/2l66 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l66 ProSAT]</span></td></tr>
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Organisms growing at elevated temperatures face the challenge of maintaining the integrity of their genetic materials. Archaea possess unique chromatin proteins for gene organization and information processing. We present the solution structure of Sso7c4 from Sulfolobus solfataricus, which has a homodimeric DNA-binding fold forming a swapped beta-loop-beta 'Tai-Chi' topology. The fold is reminiscent of the N-terminal DNA-binding domain of AbrB and MazE. In addition, several amide resonances in the heteronuclear single quantum coherence spectra of Sso7c4 are shifted and broadened with the addition of small amounts of duplex DNA oligomers. The locations of the corresponding amides in the Sso7c4 structure define its DNA-interacting surface. NMR spectra of DNA titrated with the protein further indicated that Sso7c4 interacts with DNA in the major groove. Taken together, a plausible model for the Sso7c4-DNA complex is presented, in which the DNA double helix is curved around the protein dimer.
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</table>
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== Function ==
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The DNA-recognition fold of Sso7c4 suggests a new member of SpoVT-AbrB superfamily from archaea.,Hsu CH, Wang AH Nucleic Acids Res. 2011 Aug;39(15):6764-74. Epub 2011 May 5. PMID:21546550<ref>PMID:21546550</ref>
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[https://www.uniprot.org/uniprot/D0KRA5_SACS9 D0KRA5_SACS9]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Sulfolobus solfataricus]]
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[[Category: Large Structures]]
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[[Category: Hsu, C H.]]
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[[Category: Saccharolobus solfataricus 98/2]]
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[[Category: Wang, A H.J.]]
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[[Category: Hsu C-H]]
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[[Category: Dna binding protein]]
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[[Category: Wang AH-J]]
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[[Category: Transcription regulator]]
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Current revision

The DNA-recognition fold of Sso7c4 suggests a new member of SpoVT-AbrB superfamily from archaea.

PDB ID 2l66

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