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2l74
From Proteopedia
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| - | [[Image:2l74.jpg|left|200px]] | ||
| - | + | ==Solution structure of the PilZ domain protein PA4608 complex with c-di-GMP identifies charge clustering as molecular readout== | |
| - | + | <StructureSection load='2l74' size='340' side='right'caption='[[2l74]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2l74]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L74 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L74 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C2E:9,9-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d 3,2-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)'>C2E</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l74 OCA], [https://pdbe.org/2l74 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l74 RCSB], [https://www.ebi.ac.uk/pdbsum/2l74 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l74 ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/CDGBP_PSEAE CDGBP_PSEAE] Binds the second messenger bis-(3'-5') cyclic dimeric guanosine monophosphate (c-di-GMP). Can bind two c-di-GMP molecules per monomer. May play a role in bacterial second-messenger regulated processes. Binding to c-di-GMP induces a conformational change of the C- and N-termini resulting in the exposure of a highly negative surface on one side of the protein to a possible effector protein.<ref>PMID:17096419</ref> <ref>PMID:21280119</ref> <ref>PMID:21310957</ref> | |
| - | + | == References == | |
| - | == | + | <references/> |
| - | [[2l74]] is a 1 chain structure with sequence from [ | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Pseudomonas aeruginosa]] | [[Category: Pseudomonas aeruginosa]] | ||
| - | [[Category: Allan | + | [[Category: Allan M]] |
| - | [[Category: Grzesiek | + | [[Category: Grzesiek S]] |
| - | [[Category: Habazettl | + | [[Category: Habazettl J]] |
| - | [[Category: Jenal | + | [[Category: Jenal U]] |
Current revision
Solution structure of the PilZ domain protein PA4608 complex with c-di-GMP identifies charge clustering as molecular readout
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