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2lhp

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==High resolution NMR solution structure of helix H1 of the chimpanzee HAR1 RNA==
==High resolution NMR solution structure of helix H1 of the chimpanzee HAR1 RNA==
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<StructureSection load='2lhp' size='340' side='right' caption='[[2lhp]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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<StructureSection load='2lhp' size='340' side='right'caption='[[2lhp]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2lhp]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LHP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LHP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2lhp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pan_troglodytes Pan troglodytes]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LHP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LHP FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2lhq|2lhq]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lhp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lhp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lhp RCSB], [http://www.ebi.ac.uk/pdbsum/2lhp PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lhp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lhp OCA], [https://pdbe.org/2lhp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lhp RCSB], [https://www.ebi.ac.uk/pdbsum/2lhp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lhp ProSAT]</span></td></tr>
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<table>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Comparative genomics has shown that noncoding RNAs can display substantial differences between humans and chimpanzees. The human accelerated region 1 (HAR1) is a section in the human genome that exhibits the most strongly accelerated rate of nucleotide substitution in relation to the chimpanzee genome. It is associated with higher cognitive functions in human brains. The HAR1 region of the HAR1F gene is transcribed into a 118 nt noncoding RNA. We provide experimental data to validate available secondary structure models of chimpanzee and human HAR1 RNA by utilizing CD and NMR spectroscopy and applying a "divide-and-conquer" strategy. The mutations lead to more dynamic secondary and tertiary structure in the human HAR1 RNA, presumably as part of its function. We have also determined NMR solution structures of helix H1 as the most conserved part of the chimpanzee and human HAR1 RNAs. Helix H1 contains a GAA asymmetric internal loop, the structure of which had not been solved previously. 37 nt chimpanzee and human RNA fragments (c37 and h37 RNAs) differ in a single base pair. h37 RNA folds into a slightly more stable and rigid structure than c37 RNA. Both NMR structures show structural heterogeneity of the residues corresponding to the GAA loop.
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NMR Studies of HAR1 RNA Secondary Structures Reveal Conformational Dynamics in the Human RNA.,Ziegeler M, Cevec M, Richter C, Schwalbe H Chembiochem. 2012 Sep 24;13(14):2100-12. doi: 10.1002/cbic.201200401. Epub 2012, Sep 7. PMID:22961937<ref>PMID:22961937</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cevec, M.]]
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[[Category: Large Structures]]
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[[Category: Richter, C.]]
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[[Category: Pan troglodytes]]
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[[Category: Schwalbe, H.]]
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[[Category: Cevec M]]
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[[Category: Ziegeler, M.]]
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[[Category: Richter C]]
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[[Category: Hairpin]]
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[[Category: Schwalbe H]]
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[[Category: Rna]]
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[[Category: Ziegeler M]]
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[[Category: Uucg tetraloop]]
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Current revision

High resolution NMR solution structure of helix H1 of the chimpanzee HAR1 RNA

PDB ID 2lhp

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