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2ltz

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[[Image:2ltz.jpg|left|200px]]
 
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{{STRUCTURE_2ltz| PDB=2ltz | SCENE= }}
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==Smurf2 WW3 domain in complex with a Smad7 derived peptide==
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<StructureSection load='2ltz' size='340' side='right'caption='[[2ltz]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2ltz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LTZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LTZ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ltz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ltz OCA], [https://pdbe.org/2ltz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ltz RCSB], [https://www.ebi.ac.uk/pdbsum/2ltz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ltz ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SMUF2_HUMAN SMUF2_HUMAN] E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.<ref>PMID:11389444</ref> <ref>PMID:12717440</ref>
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===Smurf2 WW3 domain in complex with a Smad7 derived peptide===
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==See Also==
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*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
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{{ABSTRACT_PUBMED_22921829}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2ltz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LTZ OCA].
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Aragon, E.]]
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[[Category: Large Structures]]
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[[Category: Gao, S.]]
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[[Category: Aragon E]]
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[[Category: Goerner, N.]]
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[[Category: Gao S]]
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[[Category: Lopes, T.]]
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[[Category: Goerner N]]
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[[Category: Macias, M J.]]
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[[Category: Lopes T]]
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[[Category: Massague, J.]]
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[[Category: Macias MJ]]
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[[Category: Xi, Q.]]
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[[Category: Massague J]]
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[[Category: Protein binding-peptide complex]]
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[[Category: Xi Q]]
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[[Category: Smad7]]
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[[Category: Smurf2]]
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[[Category: Ww]]
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Current revision

Smurf2 WW3 domain in complex with a Smad7 derived peptide

PDB ID 2ltz

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