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2lu1

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==pfsub2 solution NMR structure==
==pfsub2 solution NMR structure==
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<StructureSection load='2lu1' size='340' side='right' caption='[[2lu1]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2lu1' size='340' side='right'caption='[[2lu1]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2lu1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LU1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LU1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2lu1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LU1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LU1 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">sub-2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 Plasmodium falciparum])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lu1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lu1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lu1 RCSB], [http://www.ebi.ac.uk/pdbsum/2lu1 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lu1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lu1 OCA], [https://pdbe.org/2lu1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lu1 RCSB], [https://www.ebi.ac.uk/pdbsum/2lu1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lu1 ProSAT]</span></td></tr>
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<table>
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</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/SUB2_PLAFA SUB2_PLAFA] Serine protease which plays an essential role in the shedding of AMA1, MSP1 and MSP7 from the surface of the invading merozoite; this step is essential for productive invasion and the release of the adhesion between the erythrocyte and the merozoite (PubMed:16322767). May cleave TRAMP/PTTRAMP, thereby shedding TRAMP from the merozoite surface during erythrocyte invasion (By similarity).[UniProtKB:Q8IHZ5]<ref>PMID:16322767</ref>
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Plasmodium subtilisin 2 (Sub2) is a multi-domain protein that plays an important role in malaria infection. Here, we describe the solution NMR structure of a conserved region of the inhibitory prodomain of Sub2 from Plasmodium falciparum, termed prosub2. Despite the absence of any detectable sequence homology, the protozoan prosub2 has structural similarity to bacterial and mammalian subtilisin-like prodomains. Comparison with the three-dimensional structures of these other prodomains suggests a likely binding interface with the catalytic domain of Sub2 and provides insights into the locations of primary and secondary processing sites in Plasmodiumprodomains. Proteins 2012. (c) 2012 Wiley Periodicals, Inc.
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Solution NMR structure of a sheddase inhibitor prodomain from the malarial parasite Plasmodium falciparum.,He Y, Chen Y, Oganesyan N, Ruan B, O'Brochta D, Bryan PN, Orban J Proteins. 2012 Sep 26. doi: 10.1002/prot.24187. PMID:23011838<ref>PMID:23011838</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Plasmodium falciparum]]
[[Category: Plasmodium falciparum]]
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[[Category: Brochta, D O.]]
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[[Category: Bryan P]]
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[[Category: Bryan, P.]]
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[[Category: Chen Y]]
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[[Category: Chen, Y.]]
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[[Category: He Y]]
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[[Category: He, Y.]]
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[[Category: O'Brochta D]]
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[[Category: Orban, J.]]
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[[Category: Orban J]]
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[[Category: Ruan, B.]]
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[[Category: Ruan B]]
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[[Category: Hydrolase]]
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[[Category: Sub2 inhibitor prodomain]]
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Current revision

pfsub2 solution NMR structure

PDB ID 2lu1

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