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2lyg
From Proteopedia
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==Fuc_TBA== | ==Fuc_TBA== | ||
| - | <StructureSection load='2lyg' size='340' side='right'caption='[[2lyg | + | <StructureSection load='2lyg' size='340' side='right'caption='[[2lyg]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2lyg]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LYG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LYG FirstGlance]. <br> | <table><tr><td colspan='2'>[[2lyg]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LYG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LYG FirstGlance]. <br> | ||
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1CF:2-HYDROXYETHYL+6-DEOXY-BETA-L-GALACTOPYRANOSIDE'>1CF</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1CF:2-HYDROXYETHYL+6-DEOXY-BETA-L-GALACTOPYRANOSIDE'>1CF</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lyg OCA], [https://pdbe.org/2lyg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lyg RCSB], [https://www.ebi.ac.uk/pdbsum/2lyg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lyg ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lyg OCA], [https://pdbe.org/2lyg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lyg RCSB], [https://www.ebi.ac.uk/pdbsum/2lyg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lyg ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | Quadruplex DNA structures are attracting an enormous interest in many areas of chemistry, ranging from chemical biology, supramolecular chemistry to nanoscience. We have prepared carbohydrate-DNA conjugates containing the oligonucleotide sequences of G-quadruplexes (thrombin binding aptamer (TBA) and human telomere (TEL)), measured their thermal stability and studied their structure in solution by using NMR and molecular dynamics. The solution structure of a fucose-TBA conjugate shows stacking interactions between the carbohydrate and the DNA G-tetrad in addition to hydrogen bonding and hydrophobic contacts. We have also shown that attaching carbohydrates at the 5'-end of a quadruplex telomeric sequence can alter its folding topology. These results suggest the possibility of modulating the folding of the G-quadruplex by linking carbohydrates and have clear implications in molecular recognition and the design of new G-quadruplex ligands. | ||
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| - | Carbohydrate-DNA interactions at G-quadruplexes: folding and stability changes by attaching sugars at the 5'-end.,Gomez-Pinto I, Vengut-Climent E, Lucas R, Avino A, Eritja R, Gonzalez C, Morales JC Chemistry. 2013 Feb 4;19(6):1920-7. doi: 10.1002/chem.201203902. Epub 2013 Jan, 11. PMID:23315826<ref>PMID:23315826</ref> | ||
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 2lyg" style="background-color:#fffaf0;"></div> | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Avio | + | [[Category: Avio A]] |
| - | [[Category: Eritja | + | [[Category: Eritja R]] |
| - | [[Category: Gomez-Pinto | + | [[Category: Gomez-Pinto I]] |
| - | [[Category: Gonzalez-Ibaez | + | [[Category: Gonzalez-Ibaez C]] |
| - | [[Category: Lucas | + | [[Category: Lucas R]] |
| - | [[Category: Morales | + | [[Category: Morales J]] |
| - | [[Category: Vengut-Climent | + | [[Category: Vengut-Climent E]] |
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Current revision
Fuc_TBA
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