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2lyh
From Proteopedia
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| - | {{STRUCTURE_2lyh| PDB=2lyh | SCENE= }} | ||
| - | ===Structure of Faap24 residues 141-215=== | ||
| - | == | + | ==Structure of Faap24 residues 141-215== |
| - | [[http://www.uniprot.org/uniprot/FAP24_HUMAN FAP24_HUMAN | + | <StructureSection load='2lyh' size='340' side='right'caption='[[2lyh]]' scene=''> |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2lyh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LYH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LYH FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lyh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lyh OCA], [https://pdbe.org/2lyh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lyh RCSB], [https://www.ebi.ac.uk/pdbsum/2lyh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lyh ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/FAP24_HUMAN FAP24_HUMAN] Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Boelens | + | [[Category: Large Structures]] |
| - | [[Category: Folkers | + | [[Category: Boelens R]] |
| - | [[Category: Kaptein | + | [[Category: Folkers GE]] |
| - | [[Category: Slootweg | + | [[Category: Kaptein R]] |
| - | [[Category: Wienk | + | [[Category: Slootweg J]] |
| - | + | [[Category: Wienk H]] | |
| - | + | ||
| - | + | ||
Current revision
Structure of Faap24 residues 141-215
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