2ma2

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{{STRUCTURE_2ma2| PDB=2ma2 | SCENE= }}
 
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===Solution structure of RasGRP2 EF hands bound to calcium===
 
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{{ABSTRACT_PUBMED_23908768}}
 
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==Function==
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==Solution structure of RasGRP2 EF hands bound to calcium==
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[[http://www.uniprot.org/uniprot/GRP2_HUMAN GRP2_HUMAN]] Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activates other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway.<ref>PMID:10918068</ref> <ref>PMID:14702343</ref> <ref>PMID:17702895</ref> <ref>PMID:17576779</ref>
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<StructureSection load='2ma2' size='340' side='right'caption='[[2ma2]]' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[2ma2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MA2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MA2 FirstGlance]. <br>
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[[2ma2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MA2 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ma2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ma2 OCA], [https://pdbe.org/2ma2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ma2 RCSB], [https://www.ebi.ac.uk/pdbsum/2ma2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ma2 ProSAT]</span></td></tr>
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==Reference==
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</table>
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<ref group="xtra">PMID:023908768</ref><references group="xtra"/><references/>
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== Function ==
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[https://www.uniprot.org/uniprot/GRP2_HUMAN GRP2_HUMAN] Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activates other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway.<ref>PMID:10918068</ref> <ref>PMID:14702343</ref> <ref>PMID:17702895</ref> <ref>PMID:17576779</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Barros, T.]]
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[[Category: Large Structures]]
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[[Category: Che, Y.]]
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[[Category: Barros T]]
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[[Category: Das, R.]]
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[[Category: Che Y]]
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[[Category: Iwig, J.]]
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[[Category: Das R]]
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[[Category: Kuriyan, J.]]
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[[Category: Iwig J]]
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[[Category: Limnander, A.]]
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[[Category: Kuriyan J]]
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[[Category: Pelton, J.]]
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[[Category: Limnander A]]
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[[Category: Roose, J.]]
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[[Category: Pelton J]]
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[[Category: Vercoulen, Y.]]
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[[Category: Roose J]]
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[[Category: Wemmer, D.]]
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[[Category: Vercoulen Y]]
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[[Category: Calcium-binding protein]]
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[[Category: Wemmer D]]
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[[Category: Ef hand]]
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[[Category: Protein]]
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Current revision

Solution structure of RasGRP2 EF hands bound to calcium

PDB ID 2ma2

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