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2mki

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==Solution structure of tandem RRM domains of cytoplasmic polyadenylation element binding protein 4 (CPEB4) in complex with RNA==
==Solution structure of tandem RRM domains of cytoplasmic polyadenylation element binding protein 4 (CPEB4) in complex with RNA==
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<StructureSection load='2mki' size='340' side='right' caption='[[2mki]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2mki' size='340' side='right'caption='[[2mki]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2mki]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MKI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MKI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2mki]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MKI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MKI FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2mke|2mke]], [[2mkh|2mkh]], [[2mkj|2mkj]], [[2mkk|2mkk]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CPEB4, KIAA1673 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mki FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mki OCA], [https://pdbe.org/2mki PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mki RCSB], [https://www.ebi.ac.uk/pdbsum/2mki PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mki ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mki FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mki OCA], [http://pdbe.org/2mki PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mki RCSB], [http://www.ebi.ac.uk/pdbsum/2mki PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mki ProSAT]</span></td></tr>
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</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/CPEB4_HUMAN CPEB4_HUMAN]
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Cytoplasmic changes in polyA tail length is a key mechanism of translational control and is implicated in germline development, synaptic plasticity, cellular proliferation, senescence, and cancer progression. The presence of a U-rich cytoplasmic polyadenylation element (CPE) in the 3' untranslated regions (UTRs) of the responding mRNAs gives them the selectivity to be regulated by the CPE-binding (CPEB) family of proteins, which recognizes RNA via the tandem RNA recognition motifs (RRMs). Here we report the solution structures of the tandem RRMs of two human paralogs (CPEB1 and CPEB4) in their free and RNA-bound states. The structures reveal an unprecedented arrangement of RRMs in the free state that undergo an original closure motion upon RNA binding that ensures high fidelity. Structural and functional characterization of the ZZ domain (zinc-binding domain) of CPEB1 suggests a role in both protein-protein and protein-RNA interactions. Together with functional studies, the structures reveal how RNA binding by CPEB proteins leads to an optimal positioning of the N-terminal and ZZ domains at the 3' UTR, which favors the nucleation of the functional ribonucleoprotein complexes for translation regulation.
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A fly trap mechanism provides sequence-specific RNA recognition by CPEB proteins.,Afroz T, Skrisovska L, Belloc E, Guillen-Boixet J, Mendez R, Allain FH Genes Dev. 2014 Jul 1;28(13):1498-514. doi: 10.1101/gad.241133.114. PMID:24990967<ref>PMID:24990967</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2mki" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Afroz, T]]
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[[Category: Large Structures]]
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[[Category: Allain, F H.T]]
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[[Category: Afroz T]]
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[[Category: Belloc, E]]
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[[Category: Allain FH-T]]
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[[Category: Boixet, J G]]
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[[Category: Belloc E]]
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[[Category: Mendez, R]]
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[[Category: Boixet JG]]
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[[Category: Skrisovska, L]]
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[[Category: Mendez R]]
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[[Category: Cpeb4]]
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[[Category: Skrisovska L]]
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[[Category: Cytoplasmic polyadenylation]]
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[[Category: Protein-rna interaction]]
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[[Category: Translation regulator-rna complex]]
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[[Category: Translational regulation]]
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Solution structure of tandem RRM domains of cytoplasmic polyadenylation element binding protein 4 (CPEB4) in complex with RNA

PDB ID 2mki

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