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2n1i

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'''Unreleased structure'''
 
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The entry 2n1i is ON HOLD until Jul 06 2017
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==Structure of the PR domain from PRDM16==
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<StructureSection load='2n1i' size='340' side='right'caption='[[2n1i]]' scene=''>
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Authors: Sun, Y., Armstrong, G., Briknarova, K.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2n1i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N1I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N1I FirstGlance]. <br>
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Description: Structure of the PR domain from PRDM16
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n1i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n1i OCA], [https://pdbe.org/2n1i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n1i RCSB], [https://www.ebi.ac.uk/pdbsum/2n1i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n1i ProSAT]</span></td></tr>
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[[Category: Armstrong, G]]
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</table>
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[[Category: Briknarova, K]]
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== Disease ==
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[[Category: Sun, Y]]
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[https://www.uniprot.org/uniprot/PRD16_HUMAN PRD16_HUMAN] 1p36 deletion syndrome;Left ventricular noncompaction;Familial isolated dilated cardiomyopathy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving PRDM16 is found in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Reciprocal translocation t(1;3)(p36;q21). Isoform 4 is specifically expressed in adult T-cell leukemia.<ref>PMID:11050005</ref> <ref>PMID:12557231</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/PRD16_HUMAN PRD16_HUMAN] Binds DNA and functions as a transcriptional regulator. Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism. Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells. Functions also as a repressor of TGF-beta signaling. Isoform 4 may regulate granulocytes differentiation.<ref>PMID:12816872</ref> <ref>PMID:14656887</ref> <ref>PMID:19049980</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Armstrong G]]
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[[Category: Briknarova K]]
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[[Category: Sun Y]]

Current revision

Structure of the PR domain from PRDM16

PDB ID 2n1i

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