1rtj

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1rtj.jpg|left|200px]]
[[Image:1rtj.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1rtj |SIZE=350|CAPTION= <scene name='initialview01'>1rtj</scene>, resolution 2.35&Aring;
+
The line below this paragraph, containing "STRUCTURE_1rtj", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=CYA:TWO+OXYGEN+ATOMS+BOUND+TO+SG+OF+CYS'>CYA</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE= HIV-1 POL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1rtj| PDB=1rtj | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rtj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rtj OCA], [http://www.ebi.ac.uk/pdbsum/1rtj PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rtj RCSB]</span>
+
-
}}
+
'''MECHANISM OF INHIBITION OF HIV-1 REVERSE TRANSCRIPTASE BY NON-NUCLEOSIDE INHIBITORS'''
'''MECHANISM OF INHIBITION OF HIV-1 REVERSE TRANSCRIPTASE BY NON-NUCLEOSIDE INHIBITORS'''
Line 32: Line 29:
[[Category: Stammers, D.]]
[[Category: Stammers, D.]]
[[Category: Stuart, D.]]
[[Category: Stuart, D.]]
-
[[Category: hiv-1 reverse transcriptase]]
+
[[Category: Hiv-1 reverse transcriptase]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:53:20 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:32:42 2008''
+

Revision as of 04:53, 3 May 2008

Image:1rtj.jpg

Template:STRUCTURE 1rtj

MECHANISM OF INHIBITION OF HIV-1 REVERSE TRANSCRIPTASE BY NON-NUCLEOSIDE INHIBITORS


Overview

The structure of unliganded HIV-1 reverse transcriptase has been determined at 2.35 A resolution and refined to an R-factor of 0.219 (for all data) with good stereochemistry. The unliganded structure was produced by soaking out a weak binding non-nucleoside inhibitor, HEPT, from pregrown crystals. Comparison with the structures of four different RT and non-nucleoside inhibitor complexes reveals that only minor domain rearrangements occur, but there is a significant repositioning of a three-stranded beta-sheet in the p66 subunit (containing the catalytic aspartic acid residues 110, 185 and 186) with respect to the rest of the polymerase site. This suggests that NNIs inhibit RT by locking the polymerase active site in an inactive conformation, reminiscent of the conformation observed in the inactive p51 subunit.

About this Structure

1RTJ is a Protein complex structure of sequences from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors., Esnouf R, Ren J, Ross C, Jones Y, Stammers D, Stuart D, Nat Struct Biol. 1995 Apr;2(4):303-8. PMID:7540935 Page seeded by OCA on Sat May 3 07:53:20 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1rtj"
Personal tools