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2owi

From Proteopedia

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[[Image:2owi.gif|left|200px]]
 
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{{Structure
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==Solution structure of the RGS domain from human RGS18==
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|PDB= 2owi |SIZE=350|CAPTION= <scene name='initialview01'>2owi</scene>
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<StructureSection load='2owi' size='340' side='right'caption='[[2owi]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[2owi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2h33 2h33]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OWI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OWI FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE= RGS18, RGS13 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2owi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2owi OCA], [https://pdbe.org/2owi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2owi RCSB], [https://www.ebi.ac.uk/pdbsum/2owi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2owi ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=[[2jm5|2JM5]]
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2owi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2owi OCA], [http://www.ebi.ac.uk/pdbsum/2owi PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2owi RCSB]</span>
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[https://www.uniprot.org/uniprot/RGS18_HUMAN RGS18_HUMAN] Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha.<ref>PMID:11042171</ref> <ref>PMID:11955952</ref>
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ow/2owi_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2owi ConSurf].
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<div style="clear:both"></div>
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'''Solution structure of the RGS domain from human RGS18'''
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==See Also==
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*[[Regulator of G-protein signaling 3D structures|Regulator of G-protein signaling 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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2OWI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OWI OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C.]]
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[[Category: Arrowsmith C]]
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[[Category: Ball, L J.]]
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[[Category: Ball LJ]]
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[[Category: Bray, J.]]
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[[Category: Bray J]]
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[[Category: Brockmann, C.]]
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[[Category: Brockmann C]]
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[[Category: Diehl, A.]]
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[[Category: Diehl A]]
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[[Category: Doyle, D.]]
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[[Category: Doyle DA]]
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[[Category: Edwards, A.]]
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[[Category: Edwards A]]
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[[Category: Elkins, J.]]
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[[Category: Elkins J]]
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[[Category: Gileadi, C.]]
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[[Category: Gileadi C]]
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[[Category: Higman, V A.]]
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[[Category: Higman VA]]
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[[Category: Leidert, M.]]
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[[Category: Leidert M]]
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[[Category: Oschkinat, H.]]
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[[Category: Oschkinat H]]
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[[Category: Phillips, C.]]
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[[Category: Phillips C]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Schmieder P]]
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[[Category: Schmieder, P.]]
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[[Category: Schoch G]]
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[[Category: Schoch, G.]]
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[[Category: Soundararajan M]]
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[[Category: Soundararajan, M.]]
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[[Category: Sundstrom M]]
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[[Category: Sundstrom, M.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: Yang X]]
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[[Category: Yang, X.]]
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[[Category: sgc]]
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[[Category: signaling protein]]
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[[Category: structural genomic]]
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[[Category: structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:24:10 2008''
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Current revision

Solution structure of the RGS domain from human RGS18

PDB ID 2owi

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