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2rnm
From Proteopedia
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| - | {{Large structure}} | ||
| - | {{STRUCTURE_2rnm| PDB=2rnm | SCENE= }} | ||
| - | ===Structure of The HET-s(218-289) prion in its amyloid form obtained by solid-state NMR=== | ||
| - | {{ABSTRACT_PUBMED_18339938}} | ||
| - | == | + | ==Structure of The HET-s(218-289) prion in its amyloid form obtained by solid-state NMR== |
| - | [[2rnm]] is a 5 chain structure with sequence from [ | + | <StructureSection load='2rnm' size='340' side='right'caption='[[2rnm]]' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2rnm]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Podospora_anserina Podospora anserina]. The May 2008 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Prions'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2008_5 10.2210/rcsb_pdb/mom_2008_5]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RNM FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rnm OCA], [https://pdbe.org/2rnm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rnm RCSB], [https://www.ebi.ac.uk/pdbsum/2rnm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rnm ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HETS_PODAS HETS_PODAS] Responsible for heterokaryon incompatibility, a process that ensures that during spontaneous, vegetative cell fusion only compatible cells from the same colony survive (non-self-recognition). Forms a prion for the non-Mendelian trait [het-s]. Interacts with het-S from incompatible cells to trigger a lethal reaction that prevents the formation of viable heterokaryons. It is unknown if the native, soluble protein has a cellular function.<ref>PMID:1886611</ref> <ref>PMID:8224826</ref> <ref>PMID:9275200</ref> | ||
==See Also== | ==See Also== | ||
| - | + | *[[Prion 3D structures|Prion 3D structures]] | |
| - | *[[Prion|Prion]] | + | |
*[[Prion protein|Prion protein]] | *[[Prion protein|Prion protein]] | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Podospora anserina]] | [[Category: Podospora anserina]] | ||
[[Category: Prions]] | [[Category: Prions]] | ||
[[Category: RCSB PDB Molecule of the Month]] | [[Category: RCSB PDB Molecule of the Month]] | ||
| - | [[Category: Lange | + | [[Category: Lange A]] |
| - | [[Category: Meier | + | [[Category: Meier BH]] |
| - | + | [[Category: Riek R]] | |
| - | [[Category: Riek | + | [[Category: Siemer A]] |
| - | [[Category: Siemer | + | [[Category: Van Melckebeke H]] |
| - | [[Category: | + | [[Category: Wasmer C]] |
| - | [[Category: | + | |
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Current revision
Structure of The HET-s(218-289) prion in its amyloid form obtained by solid-state NMR
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