1rtl

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1rtl.gif|left|200px]]
[[Image:1rtl.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1rtl |SIZE=350|CAPTION= <scene name='initialview01'>1rtl</scene>, resolution 2.75&Aring;
+
The line below this paragraph, containing "STRUCTURE_1rtl", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=CPX:N-[(2R,3S)-1-((2S)-2-{[(CYCLOPENTYLAMINO)CARBONYL]AMINO}-3-METHYLBUTANOYL)-2-(1-FORMYL-1-CYCLOBUTYL)PYRROLIDINYL]CYCLOPROPANECARBOXAMIDE'>CPX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= H STRAIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11103 Hepatitis C virus])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1rtl| PDB=1rtl | SCENE= }}
-
|RELATEDENTRY=[[1n1l|1N1L]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rtl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rtl OCA], [http://www.ebi.ac.uk/pdbsum/1rtl PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rtl RCSB]</span>
+
-
}}
+
'''CRYSTAL STRUCTURE OF HCV NS3 PROTEASE DOMAIN: NS4A PEPTIDE COMPLEX WITH COVALENTLY BOUND PYRROLIDINE-5,5-TRANSLACTAM INHIBITOR'''
'''CRYSTAL STRUCTURE OF HCV NS3 PROTEASE DOMAIN: NS4A PEPTIDE COMPLEX WITH COVALENTLY BOUND PYRROLIDINE-5,5-TRANSLACTAM INHIBITOR'''
Line 27: Line 24:
[[Category: Skarzynski, T.]]
[[Category: Skarzynski, T.]]
[[Category: Somers, D O.N.]]
[[Category: Somers, D O.N.]]
-
[[Category: cofactor peptide]]
+
[[Category: Cofactor peptide]]
-
[[Category: helicase]]
+
[[Category: Helicase]]
-
[[Category: inhibitor]]
+
[[Category: Inhibitor]]
-
[[Category: nonstructural protein]]
+
[[Category: Nonstructural protein]]
-
[[Category: serine protease]]
+
[[Category: Serine protease]]
-
[[Category: translactam]]
+
[[Category: Translactam]]
-
[[Category: viral protein]]
+
[[Category: Viral protein]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:53:27 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:32:45 2008''
+

Revision as of 04:53, 3 May 2008

Image:1rtl.gif

Template:STRUCTURE 1rtl

CRYSTAL STRUCTURE OF HCV NS3 PROTEASE DOMAIN: NS4A PEPTIDE COMPLEX WITH COVALENTLY BOUND PYRROLIDINE-5,5-TRANSLACTAM INHIBITOR


Overview

[reaction: see text] In this, the first of two Letters, we describe how a P3/P4 urea linking unit was used to greatly enhance the biochemical and replicon potency of inhibitors based upon the pyrrolidine-5,5-trans-lactam template. Compound 7b demonstrated a 100 nM IC(50) in the replicon cell-based surrogate HCV assay.

About this Structure

1RTL is a Protein complex structure of sequences from Hepatitis c virus. Full crystallographic information is available from OCA.

Reference

Pyrrolidine-5,5-trans-lactams. 4. Incorporation of a P3/P4 urea leads to potent intracellular inhibitors of hepatitis C virus NS3/4A protease., Slater MJ, Amphlett EM, Andrews DM, Bamborough P, Carey SJ, Johnson MR, Jones PS, Mills G, Parry NR, Somers DO, Stewart AJ, Skarzynski T, Org Lett. 2003 Nov 27;5(24):4627-30. PMID:14627400 Page seeded by OCA on Sat May 3 07:53:27 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1rtl"
Personal tools