This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2rpq

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:05, 1 May 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2rpq.png|left|200px]]
 
-
<!--
+
==Solution Structure of a SUMO-interacting motif of MBD1-containing chromatin-associated factor 1 bound to SUMO-3==
-
The line below this paragraph, containing "STRUCTURE_2rpq", creates the "Structure Box" on the page.
+
<StructureSection load='2rpq' size='340' side='right'caption='[[2rpq]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2rpq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RPQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RPQ FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rpq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rpq OCA], [https://pdbe.org/2rpq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rpq RCSB], [https://www.ebi.ac.uk/pdbsum/2rpq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rpq ProSAT]</span></td></tr>
-
{{STRUCTURE_2rpq| PDB=2rpq | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/SUMO2_HUMAN SUMO2_HUMAN] Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.<ref>PMID:9556629</ref> <ref>PMID:18538659</ref> <ref>PMID:18408734</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rp/2rpq_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rpq ConSurf].
 +
<div style="clear:both"></div>
-
===Solution Structure of a SUMO-interacting motif of MBD1-containing chromatin-associated factor 1 bound to SUMO-3===
+
==See Also==
-
 
+
*[[SUMO 3D Structures|SUMO 3D Structures]]
-
 
+
== References ==
-
==About this Structure==
+
<references/>
-
2RPQ is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RPQ OCA].
+
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Activator]]
+
[[Category: Large Structures]]
-
[[Category: Alternative splicing]]
+
[[Category: Ariyoshi M]]
-
[[Category: Coiled coil]]
+
[[Category: Baba D]]
-
[[Category: Host-virus interaction]]
+
[[Category: Ikegami T]]
-
[[Category: Nucleus]]
+
[[Category: Ikeguchi M]]
-
[[Category: Phosphoprotein]]
+
[[Category: Saitoh H]]
-
[[Category: Polymorphism]]
+
[[Category: Sekiyama N]]
-
[[Category: Repressor]]
+
[[Category: Shirakawa M]]
-
[[Category: Sim]]
+
[[Category: Tochio H]]
-
[[Category: Sumo]]
+
[[Category: Uchimura Y]]
-
[[Category: Transcription]]
+
[[Category: Yamane T]]
-
[[Category: Transcription regulation]]
+
-
[[Category: Ubl conjugation]]
+
-
[[Category: Ubl conjugation pathway]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 05:11:21 2009''
+

Current revision

Solution Structure of a SUMO-interacting motif of MBD1-containing chromatin-associated factor 1 bound to SUMO-3

PDB ID 2rpq

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2rpq"
Personal tools