This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2v6g

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:07, 1 May 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2v6g.png|left|200px]]
 
-
<!--
+
==Structure of Progesterone 5beta-Reductase from Digitalis Lanata in complex with NADP==
-
The line below this paragraph, containing "STRUCTURE_2v6g", creates the "Structure Box" on the page.
+
<StructureSection load='2v6g' size='340' side='right'caption='[[2v6g]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2v6g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Digitalis_lanata Digitalis lanata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V6G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V6G FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-
{{STRUCTURE_2v6g| PDB=2v6g | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v6g OCA], [https://pdbe.org/2v6g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v6g RCSB], [https://www.ebi.ac.uk/pdbsum/2v6g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v6g ProSAT]</span></td></tr>
-
 
+
</table>
-
===STRUCTURE OF PROGESTERONE 5BETA-REDUCTASE FROM DIGITALIS LANATA IN COMPLEX WITH NADP===
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/5BPOR_DIGLA 5BPOR_DIGLA] Involved in cardenolide biosynthesis. Catalyzes the stereospecific conversion of progesterone to 5-beta-pregnane-3,20-dione. Can use progesterone, testosterone, 4-androstene-3,17-dione, cortisol and cortisone as substrates, but not pregnenolone, 21-OH-pregnenolone or isoprogesterone. NADPH could not be replaced by NADH.<ref>PMID:16386278</ref> <ref>PMID:18032383</ref>
-
 
+
== Evolutionary Conservation ==
-
<!--
+
[[Image:Consurf_key_small.gif|200px|right]]
-
The line below this paragraph, {{ABSTRACT_PUBMED_18032383}}, adds the Publication Abstract to the page
+
Check<jmol>
-
(as it appears on PubMed at http://www.pubmed.gov), where 18032383 is the PubMed ID number.
+
<jmolCheckbox>
-
-->
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v6/2v6g_consurf.spt"</scriptWhenChecked>
-
{{ABSTRACT_PUBMED_18032383}}
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
 
+
<text>to colour the structure by Evolutionary Conservation</text>
-
==About this Structure==
+
</jmolCheckbox>
-
2V6G is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Digitalis_lanata Digitalis lanata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V6G OCA].
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v6g ConSurf].
-
 
+
<div style="clear:both"></div>
-
==Reference==
+
== References ==
-
The Crystal Structure of Progesterone 5{beta}-Reductase from Digitalis lanata Defines a Novel Class of Short Chain Dehydrogenases/Reductases., Thorn A, Egerer-Sieber C, Jager CM, Herl V, Muller-Uri F, Kreis W, Muller YA, J Biol Chem. 2008 Jun 20;283(25):17260-17269. Epub 2007 Nov 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18032383 18032383]
+
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Digitalis lanata]]
[[Category: Digitalis lanata]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Egerer-Sieber, C.]]
+
[[Category: Egerer-Sieber C]]
-
[[Category: Herl, V.]]
+
[[Category: Herl V]]
-
[[Category: Jaeger, C.]]
+
[[Category: Jaeger C]]
-
[[Category: Kreis, W.]]
+
[[Category: Kreis W]]
-
[[Category: Mueller-Uri, F.]]
+
[[Category: Mueller-Uri F]]
-
[[Category: Muller, Y A.]]
+
[[Category: Muller YA]]
-
[[Category: Thorn, A.]]
+
[[Category: Thorn A]]
-
[[Category: Cardenolide]]
+
-
[[Category: Cardiac glycoside]]
+
-
[[Category: Oxidoreductase]]
+
-
[[Category: Reductase]]
+
-
[[Category: Sdr]]
+
-
[[Category: Tyrosine-dependent oxidoreductase]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 21:43:22 2008''
+

Current revision

Structure of Progesterone 5beta-Reductase from Digitalis Lanata in complex with NADP

PDB ID 2v6g

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2v6g"
Personal tools