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2vel

From Proteopedia

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[[Image:2vel.png|left|200px]]
 
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{{STRUCTURE_2vel| PDB=2vel | SCENE= }}
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==Structure-based enzyme engineering efforts with an inactive monomeric TIM variant: the importance of a single point mutation for generating an active site with suitable binding properties==
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<StructureSection load='2vel' size='340' side='right'caption='[[2vel]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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===STRUCTURE-BASED ENZYME ENGINEERING EFFORTS WITH AN INACTIVE MONOMERIC TIM VARIANT: THE IMPORTANCE OF A SINGLE POINT MUTATION FOR GENERATING AN ACTIVE SITE WITH SUITABLE BINDING PROPERTIES===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2vel]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VEL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VEL FirstGlance]. <br>
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{{ABSTRACT_PUBMED_18239072}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PGA:2-PHOSPHOGLYCOLIC+ACID'>PGA</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vel OCA], [https://pdbe.org/2vel PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vel RCSB], [https://www.ebi.ac.uk/pdbsum/2vel PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vel ProSAT]</span></td></tr>
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[[2vel]] is a 2 chain structure of [[TIM test]] and [[Triose Phosphate Isomerase]] with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VEL OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TPIS_TRYBB TPIS_TRYBB]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ve/2vel_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vel ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[TIM test|TIM test]]
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*[[Triose phosphate isomerase 3D structures|Triose phosphate isomerase 3D structures]]
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*[[Triose Phosphate Isomerase|Triose Phosphate Isomerase]]
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__TOC__
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</StructureSection>
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==Reference==
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[[Category: Large Structures]]
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<ref group="xtra">PMID:018239072</ref><references group="xtra"/>
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[[Category: Triose-phosphate isomerase]]
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[[Category: Trypanosoma brucei brucei]]
[[Category: Trypanosoma brucei brucei]]
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[[Category: Alahuhta, M.]]
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[[Category: Alahuhta M]]
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[[Category: Augustyns, K.]]
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[[Category: Augustyns K]]
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[[Category: Casteleijn, M G.]]
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[[Category: Casteleijn MG]]
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[[Category: El-Sayed, I.]]
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[[Category: El-Sayed I]]
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[[Category: Kemmer, C.]]
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[[Category: Kemmer C]]
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[[Category: Neubauer, P.]]
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[[Category: Neubauer P]]
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[[Category: Salin, M.]]
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[[Category: Salin M]]
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[[Category: Wierenga, R K.]]
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[[Category: Wierenga RK]]
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[[Category: Binding pocket]]
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[[Category: Engineering]]
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[[Category: Enzyme]]
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[[Category: Fatty acid biosynthesis]]
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[[Category: Gluconeogenesis]]
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[[Category: Glycolysis]]
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[[Category: Glycosome]]
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[[Category: Isomerase]]
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[[Category: Lipid synthesis]]
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[[Category: Monomeric]]
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[[Category: Pentose shunt]]
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[[Category: Substrate specificity]]
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[[Category: Tim]]
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[[Category: Tim barrel]]
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[[Category: Triosephosphate isomerase]]
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Current revision

Structure-based enzyme engineering efforts with an inactive monomeric TIM variant: the importance of a single point mutation for generating an active site with suitable binding properties

PDB ID 2vel

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