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2vxc

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{{Seed}}
 
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[[Image:2vxc.png|left|200px]]
 
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==Structure of the Crb2-BRCT2 domain complex with phosphopeptide.==
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The line below this paragraph, containing "STRUCTURE_2vxc", creates the "Structure Box" on the page.
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<StructureSection load='2vxc' size='340' side='right'caption='[[2vxc]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2vxc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VXC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VXC FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PR:PRASEODYMIUM+ION'>PR</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
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{{STRUCTURE_2vxc| PDB=2vxc | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vxc OCA], [https://pdbe.org/2vxc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vxc RCSB], [https://www.ebi.ac.uk/pdbsum/2vxc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vxc ProSAT]</span></td></tr>
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</table>
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===STRUCTURE OF THE CRB2-BRCT2 DOMAIN COMPLEX WITH PHOSPHOPEPTIDE.===
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== Function ==
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[https://www.uniprot.org/uniprot/RHP9_SCHPO RHP9_SCHPO] Essential for cell cycle arrest at the G1 and G2 stages following DNA damage by X-, and UV-irradiation, or inactivation of DNA ligase. Plays a role in the response to DNA damage.<ref>PMID:9153313</ref> <ref>PMID:9407031</ref> <ref>PMID:15550243</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 18676809 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vx/2vxc_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_18676809}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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2VXC is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VXC OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vxc ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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<ref group="xtra">PMID:18676809</ref><references group="xtra"/>
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Schizosaccharomyces pombe]]
[[Category: Schizosaccharomyces pombe]]
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[[Category: Kilkenny, M L.]]
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[[Category: Kilkenny ML]]
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[[Category: Pearl, L H.]]
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[[Category: Pearl LH]]
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[[Category: Roe, S M.]]
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[[Category: Roe SM]]
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[[Category: Brct]]
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[[Category: Cell cycle]]
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[[Category: Checkpoint signalling]]
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[[Category: Dna damage]]
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[[Category: Dna replication inhibitor]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 15:28:36 2009''
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Current revision

Structure of the Crb2-BRCT2 domain complex with phosphopeptide.

PDB ID 2vxc

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