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2xc0

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[[Image:2xc0.png|left|200px]]
 
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{{STRUCTURE_2xc0| PDB=2xc0 | SCENE= }}
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==Factor Xa in complex with a pyrrolidine-3,4-dicarboxylic acid inhibitor==
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<StructureSection load='2xc0' size='340' side='right'caption='[[2xc0]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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===FACTOR XA IN COMPLEX WITH A PYRROLIDINE-3,4-DICARBOXYLIC ACID INHIBITOR===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2xc0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XC0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XC0 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_20650636}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8NC:(3R,4R)-1-METHANESULFONYL-PYRROLIDINE-3,4--DICARBOXYLIC+ACID+3-[(3-FLUORO-4-METHOXY-PHENYL)-AMIDE]+4-{[2-FLUORO-4-(2-OXO-2H-PYRIDIN-1-YL)-PHENYL]-AMIDE}'>8NC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xc0 OCA], [https://pdbe.org/2xc0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xc0 RCSB], [https://www.ebi.ac.uk/pdbsum/2xc0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xc0 ProSAT]</span></td></tr>
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[[2xc0]] is a 2 chain structure of [[Factor Xa]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XC0 OCA].
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[https://omim.org/entry/227600 227600]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref> <ref>PMID:1973167</ref> <ref>PMID:1985698</ref> <ref>PMID:7669671</ref> <ref>PMID:8529633</ref> <ref>PMID:7860069</ref> <ref>PMID:8845463</ref> <ref>PMID:8910490</ref> <ref>PMID:10468877</ref> <ref>PMID:10746568</ref> <ref>PMID:10739379</ref> <ref>PMID:11248282</ref> <ref>PMID:11728527</ref> <ref>PMID:12945883</ref> <ref>PMID:15650540</ref> <ref>PMID:17393015</ref> <ref>PMID:19135706</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xc/2xc0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2xc0 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Factor Xa|Factor Xa]]
*[[Factor Xa|Factor Xa]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:020650636</ref><references group="xtra"/>
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__TOC__
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[[Category: Coagulation factor Xa]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Anselm, L.]]
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[[Category: Large Structures]]
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[[Category: Banner, D W.]]
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[[Category: Anselm L]]
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[[Category: Benz, J.]]
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[[Category: Banner DW]]
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[[Category: Haap, W.]]
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[[Category: Benz J]]
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[[Category: Schlatter, D.]]
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[[Category: Haap W]]
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[[Category: Blood clotting]]
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[[Category: Schlatter D]]
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[[Category: Coagulation factor]]
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[[Category: Hydrolase]]
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[[Category: Hydroxylation]]
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[[Category: Serine protease]]
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[[Category: Zymogen]]
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Current revision

Factor Xa in complex with a pyrrolidine-3,4-dicarboxylic acid inhibitor

PDB ID 2xc0

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