2xwc
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 2xwc is ON HOLD Authors: Canning, P., Zhang, Y., Vollmar, M., Krojer, T., Ugochukwu, E., Muniz, J.R.C., Von Delft, F., Weigelt, J., Arrowsmith, C.H....) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the DNA binding domain of human TP73 refined at 1.8 A resolution== | |
| + | <StructureSection load='2xwc' size='340' side='right'caption='[[2xwc]], [[Resolution|resolution]] 1.82Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2xwc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2xip 2xip]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XWC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XWC FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xwc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xwc OCA], [https://pdbe.org/2xwc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xwc RCSB], [https://www.ebi.ac.uk/pdbsum/2xwc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xwc ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/P73_HUMAN P73_HUMAN] Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.<ref>PMID:11753569</ref> <ref>PMID:10203277</ref> <ref>PMID:18174154</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[P73|P73]] | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith CH]] | ||
| + | [[Category: Bountra C]] | ||
| + | [[Category: Bullock AN]] | ||
| + | [[Category: Canning P]] | ||
| + | [[Category: Edwards AM]] | ||
| + | [[Category: Krojer T]] | ||
| + | [[Category: Muniz JRC]] | ||
| + | [[Category: Ugochukwu E]] | ||
| + | [[Category: Vollmar M]] | ||
| + | [[Category: Weigelt J]] | ||
| + | [[Category: Zhang Y]] | ||
| + | [[Category: Von Delft F]] | ||
Current revision
Crystal structure of the DNA binding domain of human TP73 refined at 1.8 A resolution
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bountra C | Bullock AN | Canning P | Edwards AM | Krojer T | Muniz JRC | Ugochukwu E | Vollmar M | Weigelt J | Zhang Y | Von Delft F
