This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4a6h

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:13, 1 May 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 4a6h is ON HOLD until Paper Publication
+
==Crystal structure of Slm1-PH domain in complex with Inositol-4- phosphate==
-
 
+
<StructureSection load='4a6h' size='340' side='right'caption='[[4a6h]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
-
Authors: Anand, K., Maeda, K., Gavin, A.C.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[4a6h]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A6H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A6H FirstGlance]. <br>
-
Description: Crystal structure of Slm1-PH domain in complex with Inositol-4-phosphate
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.449&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I4D:D-MYO-INOSITOL-4-PHOSPHATE'>I4D</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a6h OCA], [https://pdbe.org/4a6h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a6h RCSB], [https://www.ebi.ac.uk/pdbsum/4a6h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a6h ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/SLM1_YEAST SLM1_YEAST] Together with SLM2, effector of the TORC2- and calcineurin-signaling pathways. Phosphorylated and activated by TORC2 under favorable growth conditions. Mediates actin polarization via inhibition of calcineurin-dependent transcription. Upon nutrient limitation or environmental stress, gets dephosphorylated by calcineurin. Dephosphorylation inhibits its interaction with TORC2, thereby antagonizing TORC2 signaling and mediating calcineurin-dependent actin depolarization. Also functions in heat-induced, calcineurin-mediated uracil permease (FUR4) endocytosis.<ref>PMID:15372071</ref> <ref>PMID:15689497</ref> <ref>PMID:16959779</ref> <ref>PMID:16738335</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
 +
[[Category: Saccharomyces cerevisiae]]
 +
[[Category: Anand K]]
 +
[[Category: Gavin AC]]
 +
[[Category: Maeda K]]

Current revision

Crystal structure of Slm1-PH domain in complex with Inositol-4- phosphate

PDB ID 4a6h

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4a6h"
Personal tools