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4a7i

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[[Image:4a7i.png|left|200px]]
 
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{{STRUCTURE_4a7i| PDB=4a7i | SCENE= }}
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==Factor Xa in complex with a potent 2-amino-ethane sulfonamide inhibitor==
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<StructureSection load='4a7i' size='340' side='right'caption='[[4a7i]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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===Factor Xa in complex with a potent 2-amino-ethane sulfonamide inhibitor===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4a7i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A7I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A7I FirstGlance]. <br>
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{{ABSTRACT_PUBMED_22190348}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A7I:5-CHLORO-THIOPHENE-2-CARBOXYLIC+ACID+[2-(1--ISOPROPYL-PIPERIDIN-4-YLSULFAMOYL)-ETHYL]-AMIDE'>A7I</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a7i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a7i OCA], [https://pdbe.org/4a7i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a7i RCSB], [https://www.ebi.ac.uk/pdbsum/4a7i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a7i ProSAT]</span></td></tr>
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[[4a7i]] is a 2 chain structure of [[Factor Xa]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A7I OCA].
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[https://omim.org/entry/227600 227600]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref> <ref>PMID:1973167</ref> <ref>PMID:1985698</ref> <ref>PMID:7669671</ref> <ref>PMID:8529633</ref> <ref>PMID:7860069</ref> <ref>PMID:8845463</ref> <ref>PMID:8910490</ref> <ref>PMID:10468877</ref> <ref>PMID:10746568</ref> <ref>PMID:10739379</ref> <ref>PMID:11248282</ref> <ref>PMID:11728527</ref> <ref>PMID:12945883</ref> <ref>PMID:15650540</ref> <ref>PMID:17393015</ref> <ref>PMID:19135706</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
==See Also==
==See Also==
*[[Factor Xa|Factor Xa]]
*[[Factor Xa|Factor Xa]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:022190348</ref><references group="xtra"/>
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__TOC__
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[[Category: Coagulation factor Xa]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bauer, A.]]
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[[Category: Large Structures]]
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[[Category: Czech, J.]]
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[[Category: Bauer A]]
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[[Category: Matter, H.]]
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[[Category: Czech J]]
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[[Category: Nazare, M.]]
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[[Category: Matter H]]
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[[Category: Ritter, K.]]
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[[Category: Nazare M]]
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[[Category: Schreuder, H.]]
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[[Category: Ritter K]]
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[[Category: Urmann, M.]]
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[[Category: Schreuder H]]
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[[Category: Wagner, M.]]
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[[Category: Urmann M]]
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[[Category: Wehner, V.]]
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[[Category: Wagner M]]
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[[Category: Will, D W.]]
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[[Category: Wehner V]]
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[[Category: Blood coagulation factor]]
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[[Category: Will DW]]
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[[Category: Calcium- binding]]
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[[Category: Egf-like domain]]
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[[Category: Gamma-carboxyglutamic acid]]
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[[Category: Glycoprotein]]
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[[Category: Hydrolase]]
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[[Category: Hydroxylation]]
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[[Category: Serine protease]]
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[[Category: Serine proteinase]]
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Current revision

Factor Xa in complex with a potent 2-amino-ethane sulfonamide inhibitor

PDB ID 4a7i

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