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4acx
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Aminoimidazoles as BACE-1 Inhibitors. X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH COMPOUND 23== | |
| + | <StructureSection load='4acx' size='340' side='right'caption='[[4acx]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4acx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ACX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ACX FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=S8Z:(8R)-8-[4-(DIFLUOROMETHOXY)PHENYL]-3,3-DIFLUORO-8-[3-(3-METHOXYPROP-1-YN-1-YL)PHENYL]-2,3,4,8-TETRAHYDROIMIDAZO[1,5-A]PYRIMIDIN-6-AMINE'>S8Z</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4acx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4acx OCA], [https://pdbe.org/4acx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4acx RCSB], [https://www.ebi.ac.uk/pdbsum/4acx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4acx ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Beta secretase 3D structures|Beta secretase 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Berg S]] | ||
| + | [[Category: Ek M]] | ||
| + | [[Category: Falting J]] | ||
| + | [[Category: Georgievska B]] | ||
| + | [[Category: Gustavsson S]] | ||
| + | [[Category: Holenz J]] | ||
| + | [[Category: Kihlstrom J]] | ||
| + | [[Category: Kolmodin K]] | ||
| + | [[Category: Lindstrom J]] | ||
| + | [[Category: Neelissen J]] | ||
| + | [[Category: Olsson LL]] | ||
| + | [[Category: Plobeck N]] | ||
| + | [[Category: Rotticci D]] | ||
| + | [[Category: Sehgelmeble F]] | ||
| + | [[Category: Sundstrom M]] | ||
| + | [[Category: Swahn B]] | ||
| + | [[Category: Von Berg S]] | ||
Current revision
Aminoimidazoles as BACE-1 Inhibitors. X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH COMPOUND 23
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Categories: Homo sapiens | Large Structures | Berg S | Ek M | Falting J | Georgievska B | Gustavsson S | Holenz J | Kihlstrom J | Kolmodin K | Lindstrom J | Neelissen J | Olsson LL | Plobeck N | Rotticci D | Sehgelmeble F | Sundstrom M | Swahn B | Von Berg S
