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4ayp

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Structure of The GH47 processing alpha-1,2-mannosidase from Caulobacter strain K31 in complex with thiomannobioside

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 ==Structure of The GH47 processing alpha-1,2-mannosidase from Caulobacter strain K31 in complex with thiomannobioside==
-<StructureSection load='4ayp' size='340' side='right' caption='[[4ayp]], [[Resolution|resolution]] 0.85&Aring;' scene=''>
+<StructureSection load='4ayp' size='340' side='right'caption='[[4ayp]], [[Resolution|resolution]] 0.85&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4ayp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Caulobacter_sp._k31 Caulobacter sp. k31]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AYP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AYP FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4ayp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caulobacter_sp._K31 Caulobacter sp. K31]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AYP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AYP FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SMD:METHYL-2-S-(ALPHA-D-MANNOPYRANOSYL)-2-THIO-ALPHA-D-MANNOPYRANOSIDE'>SMD</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.85&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ayo|4ayo]], [[4ayq|4ayq]], [[4ayr|4ayr]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PRD_900033:methyl+2-S-alpha-D-mannopyranosyl-2-thio-alpha-D-mannopyranoside'>PRD_900033</scene>, <scene name='pdbligand=Z5L:methyl+2-thio-alpha-D-mannopyranoside'>Z5L</scene></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannosyl-oligosaccharide_1,2-alpha-mannosidase Mannosyl-oligosaccharide 1,2-alpha-mannosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.113 3.2.1.113] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ayp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ayp OCA], [https://pdbe.org/4ayp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ayp RCSB], [https://www.ebi.ac.uk/pdbsum/4ayp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ayp ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ayp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ayp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ayp RCSB], [http://www.ebi.ac.uk/pdbsum/4ayp PDBsum]</span></td></tr>
 </table>
-<div style="background-color:#fffaf0;">
+== Function ==
-== Publication Abstract from PubMed ==
+[https://www.uniprot.org/uniprot/B0SWV2_CAUSK B0SWV2_CAUSK]
-Mannosides in the southern hemisphere: Conformational analysis of enzymatic mannoside hydrolysis informs strategies for enzyme inhibition and inspires solutions to mannoside synthesis. Atomic resolution structures along the reaction coordinate of an inverting alpha-mannosidase show how the enzyme distorts the substrate and transition state. QM/MM calculations reveal how the free energy landscape of isolated alpha-D-mannose is molded on enzyme to only allow one conformationally accessible reaction coordinate.
-The reaction coordinate of a bacterial GH47 alpha-mannosidase: a combined quantum mechanical and structural approach.,Thompson AJ, Dabin J, Iglesias-Fernandez J, Ardevol A, Dinev Z, Williams SJ, Bande O, Siriwardena A, Moreland C, Hu TC, Smith DK, Gilbert HJ, Rovira C, Davies GJ Angew Chem Int Ed Engl. 2012 Oct 29;51(44):10997-1001. doi:, 10.1002/anie.201205338. Epub 2012 Sep 26. PMID:23012075<ref>PMID:23012075</ref>
-From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-</div>
 ==See Also==
-*[[Mannosidase|Mannosidase]]
+*[[Mannosidase 3D structures|Mannosidase 3D structures]]
-== References ==
-<references/>
 __TOC__
 </StructureSection>
-[[Category: Caulobacter sp. k31]]
+[[Category: Caulobacter sp. K31]]
-[[Category: Mannosyl-oligosaccharide 1,2-alpha-mannosidase]]
+[[Category: Large Structures]]
-[[Category: Dabin, J]]
+[[Category: Dabin J]]
-[[Category: Davies, G J]]
+[[Category: Davies GJ]]
-[[Category: Dinev, Z]]
+[[Category: Dinev Z]]
-[[Category: Gilbert, H J]]
+[[Category: Gilbert HJ]]
-[[Category: Hu, T C]]
+[[Category: Hu TC]]
-[[Category: Iglesias-Fernandez, A]]
+[[Category: Iglesias-Fernandez A]]
-[[Category: Iglesias-Fernandez, J]]
+[[Category: Iglesias-Fernandez J]]
-[[Category: Moreland, C]]
+[[Category: Moreland C]]
-[[Category: Rovira, C]]
+[[Category: Rovira C]]
-[[Category: Siriwardena, A]]
+[[Category: Siriwardena A]]
-[[Category: Smith, D K]]
+[[Category: Smith DK]]
-[[Category: Thompson, A J]]
+[[Category: Thompson AJ]]
-[[Category: Williams, S J]]
+[[Category: Williams SJ]]
-[[Category: Cazy]]
-[[Category: Enzyme-carbohydrate interaction]]
-[[Category: Gh47]]
-[[Category: Glycosidase inhibition]]
-[[Category: Glycoside hydrolase]]
-[[Category: Hydrolase]]
-[[Category: Mannose]]
-[[Category: Quantum mechanic]]

4ayp

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Structure of The GH47 processing alpha-1,2-mannosidase from Caulobacter strain K31 in complex with thiomannobioside

Structural highlights

Function

See Also

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