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4b05

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'''Unreleased structure'''
 
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The entry 4b05 is ON HOLD
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==Preclinical characterization of AZD3839, a novel clinical candidate BACE1 inhibitor for the treatment of Alzheimer Disease==
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<StructureSection load='4b05' size='340' side='right'caption='[[4b05]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4b05]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B05 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B05 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=32D:(1S)-1-[2-(DIFLUOROMETHYL)PYRIDIN-4-YL]-4-FLUORO-1-(3-PYRIMIDIN-5-YLPHENYL)-1H-ISOINDOL-3-AMINE'>32D</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b05 OCA], [https://pdbe.org/4b05 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b05 RCSB], [https://www.ebi.ac.uk/pdbsum/4b05 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b05 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
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Authors: Jeppsson, F., Eketjall, S., Janson, J., Karlstrom, S., Gustavsson, S., Olsson, L.L., Radesater, A., Ploeger, B., Cebers, G., Kolmodin, K., Swahn, B., vonBerg, S., Bueters, T., Falting, J.
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==See Also==
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*[[Beta secretase 3D structures|Beta secretase 3D structures]]
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Description: Preclinical characterization of AZD3839, a novel clinical candidate BACE1 inhibitor for the treatment of Alzheimer Disease
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Bueters T]]
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[[Category: Cebers G]]
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[[Category: Eketjall S]]
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[[Category: Falting J]]
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[[Category: Gustavsson S]]
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[[Category: Janson J]]
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[[Category: Jeppsson F]]
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[[Category: Karlstrom S]]
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[[Category: Kolmodin K]]
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[[Category: Olsson LL]]
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[[Category: Ploeger B]]
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[[Category: Radesater AC]]
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[[Category: Swahn BM]]
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[[Category: Von Berg S]]

Current revision

Preclinical characterization of AZD3839, a novel clinical candidate BACE1 inhibitor for the treatment of Alzheimer Disease

PDB ID 4b05

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