4b95

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(New page: '''Unreleased structure''' The entry 4b95 is ON HOLD Authors: Buckley, D.L., Gustafson, J.L., VanMolle, I., Roth, A.G., SeopTae, H., Gareiss, P.C., Jorgensen, W.L., Ciulli, A., Crews, C...)
Current revision (07:17, 1 May 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 4b95 is ON HOLD
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==pVHL-EloB-EloB-EloC complex_(2S,4R)-1-(2-chlorophenyl)carbonyl-N-[(4-chlorophenyl)methyl]-4-oxidanyl-pyrrolidine-2-carboxamide bound==
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<StructureSection load='4b95' size='340' side='right'caption='[[4b95]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4b95]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B95 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B95 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=UCK:(2S,4R)-1-(2-CHLOROPHENYL)CARBONYL-N-[(4-CHLOROPHENYL)METHYL]-4-OXIDANYL-PYRROLIDINE-2-CARBOXAMIDE'>UCK</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b95 OCA], [https://pdbe.org/4b95 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b95 RCSB], [https://www.ebi.ac.uk/pdbsum/4b95 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b95 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ELOB_HUMAN ELOB_HUMAN] SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).<ref>PMID:7638163</ref> <ref>PMID:15590694</ref> The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.<ref>PMID:7638163</ref> <ref>PMID:15590694</ref>
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Authors: Buckley, D.L., Gustafson, J.L., VanMolle, I., Roth, A.G., SeopTae, H., Gareiss, P.C., Jorgensen, W.L., Ciulli, A., Crews, C.M.
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==See Also==
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*[[Elongation factor 3D structures|Elongation factor 3D structures]]
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Description: pVHL-EloB-EloC complex_3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO1,2-.C. PYRAZOLE bound
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Buckley DL]]
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[[Category: Ciulli A]]
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[[Category: Crews CM]]
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[[Category: Gareiss PC]]
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[[Category: Gustafson JL]]
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[[Category: Jorgensen WL]]
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[[Category: Roth AG]]
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[[Category: SeopTae H]]
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[[Category: VanMolle I]]

Current revision

pVHL-EloB-EloB-EloC complex_(2S,4R)-1-(2-chlorophenyl)carbonyl-N-[(4-chlorophenyl)methyl]-4-oxidanyl-pyrrolidine-2-carboxamide bound

PDB ID 4b95

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