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4btt

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(New page: '''Unreleased structure''' The entry 4btt is ON HOLD until Paper Publication Authors: Meneyrol, J., Follmann, M., Lassalle, G., Wehner, V., Barre, G., Rousseaux, T., Altenburger, J.M., ...)
Current revision (07:17, 1 May 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 4btt is ON HOLD until Paper Publication
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==factor Xa in complex with the dual thrombin-FXa inhibitor 31.==
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<StructureSection load='4btt' size='340' side='right'caption='[[4btt]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4btt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BTT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BTT FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.59&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=VYR:N-[(S)-1-[5-(5-CHLORO-THIOPHEN-2-YL)-ISOXAZOL-3-YLMETHYL]-2-(4-METHOXY-PIPERIDIN-1-YL)-2-OXO-ETHYL]-2-ETHYL-3-(3-OXO-MORPHOLIN-4-YL)-BENZENESULFONAMIDE'>VYR</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4btt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4btt OCA], [https://pdbe.org/4btt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4btt RCSB], [https://www.ebi.ac.uk/pdbsum/4btt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4btt ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[https://omim.org/entry/227600 227600]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref> <ref>PMID:1973167</ref> <ref>PMID:1985698</ref> <ref>PMID:7669671</ref> <ref>PMID:8529633</ref> <ref>PMID:7860069</ref> <ref>PMID:8845463</ref> <ref>PMID:8910490</ref> <ref>PMID:10468877</ref> <ref>PMID:10746568</ref> <ref>PMID:10739379</ref> <ref>PMID:11248282</ref> <ref>PMID:11728527</ref> <ref>PMID:12945883</ref> <ref>PMID:15650540</ref> <ref>PMID:17393015</ref> <ref>PMID:19135706</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
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Authors: Meneyrol, J., Follmann, M., Lassalle, G., Wehner, V., Barre, G., Rousseaux, T., Altenburger, J.M., Petit, F., Bocskei, Z., Stehlin-Gaon, C., Schreuder, H., Alet, N., Herault, J.-P., Millet, L., Dol, F., Hasbrand, C., Schaeffer, P., Sadoun, F., Klieber, S., Briot, C., Bono, F., Herbert, J.-M.
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==See Also==
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*[[Factor Xa|Factor Xa]]
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Description: factor Xa in complex with the dual thrombin-FXa inhibitor 31.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Alet N]]
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[[Category: Altenburger JM]]
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[[Category: Barre G]]
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[[Category: Bocskei Z]]
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[[Category: Bono F]]
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[[Category: Briot C]]
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[[Category: Dol F]]
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[[Category: Follmann M]]
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[[Category: Hasbrand C]]
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[[Category: Herault J-P]]
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[[Category: Herbert J-M]]
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[[Category: Klieber S]]
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[[Category: Lassalle G]]
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[[Category: Meneyrol J]]
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[[Category: Millet L]]
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[[Category: Petit F]]
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[[Category: Rousseaux T]]
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[[Category: Sadoun F]]
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[[Category: Schaeffer P]]
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[[Category: Schreuder H]]
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[[Category: Stehlin-Gaon C]]
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[[Category: Wehner V]]

Current revision

factor Xa in complex with the dual thrombin-FXa inhibitor 31.

PDB ID 4btt

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