This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4btt

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "4btt" [edit=sysop:move=sysop])
Current revision (07:17, 1 May 2024) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 4btt is ON HOLD until Paper Publication
+
==factor Xa in complex with the dual thrombin-FXa inhibitor 31.==
 +
<StructureSection load='4btt' size='340' side='right'caption='[[4btt]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[4btt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BTT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BTT FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.59&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=VYR:N-[(S)-1-[5-(5-CHLORO-THIOPHEN-2-YL)-ISOXAZOL-3-YLMETHYL]-2-(4-METHOXY-PIPERIDIN-1-YL)-2-OXO-ETHYL]-2-ETHYL-3-(3-OXO-MORPHOLIN-4-YL)-BENZENESULFONAMIDE'>VYR</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4btt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4btt OCA], [https://pdbe.org/4btt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4btt RCSB], [https://www.ebi.ac.uk/pdbsum/4btt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4btt ProSAT]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[https://omim.org/entry/227600 227600]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref> <ref>PMID:1973167</ref> <ref>PMID:1985698</ref> <ref>PMID:7669671</ref> <ref>PMID:8529633</ref> <ref>PMID:7860069</ref> <ref>PMID:8845463</ref> <ref>PMID:8910490</ref> <ref>PMID:10468877</ref> <ref>PMID:10746568</ref> <ref>PMID:10739379</ref> <ref>PMID:11248282</ref> <ref>PMID:11728527</ref> <ref>PMID:12945883</ref> <ref>PMID:15650540</ref> <ref>PMID:17393015</ref> <ref>PMID:19135706</ref>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
-
Authors: Meneyrol, J., Follmann, M., Lassalle, G., Wehner, V., Barre, G., Rousseaux, T., Altenburger, J.M., Petit, F., Bocskei, Z., Stehlin-Gaon, C., Schreuder, H., Alet, N., Herault, J.-P., Millet, L., Dol, F., Hasbrand, C., Schaeffer, P., Sadoun, F., Klieber, S., Briot, C., Bono, F., Herbert, J.-M.
+
==See Also==
-
 
+
*[[Factor Xa|Factor Xa]]
-
Description: factor Xa in complex with the dual thrombin-FXa inhibitor 31.
+
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Alet N]]
 +
[[Category: Altenburger JM]]
 +
[[Category: Barre G]]
 +
[[Category: Bocskei Z]]
 +
[[Category: Bono F]]
 +
[[Category: Briot C]]
 +
[[Category: Dol F]]
 +
[[Category: Follmann M]]
 +
[[Category: Hasbrand C]]
 +
[[Category: Herault J-P]]
 +
[[Category: Herbert J-M]]
 +
[[Category: Klieber S]]
 +
[[Category: Lassalle G]]
 +
[[Category: Meneyrol J]]
 +
[[Category: Millet L]]
 +
[[Category: Petit F]]
 +
[[Category: Rousseaux T]]
 +
[[Category: Sadoun F]]
 +
[[Category: Schaeffer P]]
 +
[[Category: Schreuder H]]
 +
[[Category: Stehlin-Gaon C]]
 +
[[Category: Wehner V]]

Current revision

factor Xa in complex with the dual thrombin-FXa inhibitor 31.

PDB ID 4btt

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4btt"
Personal tools