4zgo

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<StructureSection load='4zgo' size='340' side='right'caption='[[4zgo]], [[Resolution|resolution]] 2.06&Aring;' scene=''>
<StructureSection load='4zgo' size='340' side='right'caption='[[4zgo]], [[Resolution|resolution]] 2.06&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4zgo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZGO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZGO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4zgo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZGO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZGO FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cdc123, SPAP27G11.03 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 CBS 356])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.063&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zgo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zgo OCA], [http://pdbe.org/4zgo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zgo RCSB], [http://www.ebi.ac.uk/pdbsum/4zgo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zgo ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zgo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zgo OCA], [https://pdbe.org/4zgo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zgo RCSB], [https://www.ebi.ac.uk/pdbsum/4zgo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zgo ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CD123_SCHPO CD123_SCHPO]] Regulates the cell cycle in a nutrient dependent manner.
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[https://www.uniprot.org/uniprot/CD123_SCHPO CD123_SCHPO] Regulates the cell cycle in a nutrient dependent manner.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Eukaryotic initiation factor 2 (eIF2), a heterotrimeric guanosine triphosphatase, has a central role in protein biosynthesis by supplying methionylated initiator tRNA to the ribosomal translation initiation complex and by serving as a target for translational control in response to stress. Recent work identified a novel step indispensable for eIF2 function: assembly of eIF2 from its three subunits by the cell proliferation protein Cdc123. We report the first crystal structure of a Cdc123 representative, that from Schizosaccharomyces pombe, both isolated and bound to domain III of Saccharomyces cerevisiae eIF2gamma. The structures show that Cdc123 resembles enzymes of the ATP-grasp family. Indeed, Cdc123 binds ATP-Mg(2+), and conserved residues contacting ATP-Mg(2+) are essential for Cdc123 to support eIF2 assembly and cell viability. A docking of eIF2alphagamma onto Cdc123, combined with genetic and biochemical experiments, allows us to propose a model explaining how Cdc123 participates in the biogenesis of eIF2 through facilitating assembly of eIF2gamma to eIF2alpha.
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Cdc123, a Cell Cycle Regulator Needed for eIF2 Assembly, Is an ATP-Grasp Protein with Unique Features.,Panvert M, Dubiez E, Arnold L, Perez J, Mechulam Y, Seufert W, Schmitt E Structure. 2015 Sep 1;23(9):1596-608. doi: 10.1016/j.str.2015.06.014. Epub 2015, Jul 23. PMID:26211610<ref>PMID:26211610</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4zgo" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cbs 356]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arnold, L]]
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[[Category: Schizosaccharomyces pombe]]
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[[Category: Dubiez, E]]
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[[Category: Arnold L]]
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[[Category: Mechulam, Y]]
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[[Category: Dubiez E]]
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[[Category: Panvert, M]]
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[[Category: Mechulam Y]]
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[[Category: Perez, J]]
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[[Category: Panvert M]]
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[[Category: Schmitt, E]]
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[[Category: Perez J]]
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[[Category: Seufert, W]]
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[[Category: Schmitt E]]
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[[Category: Atp-grap fold]]
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[[Category: Seufert W]]
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[[Category: Cell cycle]]
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[[Category: Eif2 assembly]]
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Current revision

Structure of C-terminally truncated Cdc123 from Schizosaccharomyces pombe

PDB ID 4zgo

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