This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4zi1

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:20, 1 May 2024) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
==HUMAN ESTROGEN RECEPTOR BETA LIGAND-BINDING DOMAIN IN COMPLEX WITH KB095285 AND CIA12 COACTIVATOR PEPTIDE==
==HUMAN ESTROGEN RECEPTOR BETA LIGAND-BINDING DOMAIN IN COMPLEX WITH KB095285 AND CIA12 COACTIVATOR PEPTIDE==
-
<StructureSection load='4zi1' size='340' side='right' caption='[[4zi1]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
+
<StructureSection load='4zi1' size='340' side='right'caption='[[4zi1]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4zi1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZI1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZI1 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4zi1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZI1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZI1 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KB0:2-(4-HYDROXYPHENYL)-7-METHYL-3-PHENYL-1H-INDEN-5-OL'>KB0</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zi1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zi1 OCA], [http://pdbe.org/4zi1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zi1 RCSB], [http://www.ebi.ac.uk/pdbsum/4zi1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zi1 ProSAT]</span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KB0:2-(4-HYDROXYPHENYL)-7-METHYL-3-PHENYL-1H-INDEN-5-OL'>KB0</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zi1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zi1 OCA], [https://pdbe.org/4zi1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zi1 RCSB], [https://www.ebi.ac.uk/pdbsum/4zi1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zi1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/ESR2_HUMAN ESR2_HUMAN]] Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual. [[http://www.uniprot.org/uniprot/NCOA5_HUMAN NCOA5_HUMAN]] Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2).<ref>PMID:15073177</ref>
+
[https://www.uniprot.org/uniprot/ESR2_HUMAN ESR2_HUMAN] Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
-
== References ==
+
 
-
<references/>
+
==See Also==
 +
*[[Estrogen receptor 3D structures|Estrogen receptor 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Bonn, T]]
+
[[Category: Homo sapiens]]
-
[[Category: Kauppi, B]]
+
[[Category: Large Structures]]
-
[[Category: Beta selective]]
+
[[Category: Bonn T]]
-
[[Category: Erb]]
+
[[Category: Kauppi B]]
-
[[Category: Estrogen receptor beta]]
+
-
[[Category: Signaling protein]]
+

Current revision

HUMAN ESTROGEN RECEPTOR BETA LIGAND-BINDING DOMAIN IN COMPLEX WITH KB095285 AND CIA12 COACTIVATOR PEPTIDE

PDB ID 4zi1

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4zi1"
Personal tools