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5agx

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'''Unreleased structure'''
 
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The entry 5agx is ON HOLD
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==Bcl-2 alpha beta-1 LINEAR complex==
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<StructureSection load='5agx' size='340' side='right'caption='[[5agx]], [[Resolution|resolution]] 2.24&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5agx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AGX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AGX FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.24&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=AJE:(3S,4R)-4-AMINO-1-(3-CARBOXYPROPANOYL)PYRROLIDINE-3-CARBOXYLIC+ACID'>AJE</scene>, <scene name='pdbligand=MH8:(2S)-2-AMINO-2-METHYLHEPT-6-ENOIC+ACID'>MH8</scene>, <scene name='pdbligand=XCP:(1S,2S)-2-AMINOCYCLOPENTANECARBOXYLIC+ACID'>XCP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5agx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5agx OCA], [https://pdbe.org/5agx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5agx RCSB], [https://www.ebi.ac.uk/pdbsum/5agx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5agx ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN] Note=A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.
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== Function ==
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[https://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN] Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).<ref>PMID:18570871</ref> [https://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>
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Authors: Smith, B.J., F Lee, E., Checco, J.W., Gellman, S.H., Fairlie, W.D.
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==See Also==
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*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
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Description: Bcl-2 alpha beta-1 LINEAR complex
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Fairlie, W.D]]
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__TOC__
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[[Category: Checco, J.W]]
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</StructureSection>
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[[Category: F Lee, E]]
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[[Category: Homo sapiens]]
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[[Category: Gellman, S.H]]
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[[Category: Large Structures]]
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[[Category: Smith, B.J]]
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[[Category: Checco JW]]
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[[Category: F Lee E]]
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[[Category: Fairlie WD]]
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[[Category: Gellman SH]]
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[[Category: Smith BJ]]

Current revision

Bcl-2 alpha beta-1 LINEAR complex

PDB ID 5agx

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