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5dpn

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==Engineered CBM X-2 L110F in complex with branched carbohydrate XXXG.==
==Engineered CBM X-2 L110F in complex with branched carbohydrate XXXG.==
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<StructureSection load='5dpn' size='340' side='right' caption='[[5dpn]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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<StructureSection load='5dpn' size='340' side='right'caption='[[5dpn]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5dpn]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DPN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DPN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5dpn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodothermus_marinus Rhodothermus marinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DPN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DPN FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DOD:DEUTERATED+WATER'>DOD</scene>, <scene name='pdbligand=XYS:XYLOPYRANOSE'>XYS</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Hybrid , Neutron Diffraction , X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dpn OCA], [http://pdbe.org/5dpn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dpn RCSB], [http://www.ebi.ac.uk/pdbsum/5dpn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dpn ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DOD:DEUTERATED+WATER'>DOD</scene>, <scene name='pdbligand=XYS:XYLOPYRANOSE'>XYS</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dpn OCA], [https://pdbe.org/5dpn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dpn RCSB], [https://www.ebi.ac.uk/pdbsum/5dpn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dpn ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q7WTN6_RHOMR Q7WTN6_RHOMR]
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Carbohydrate-binding modules (CBMs) are key components of many carbohydrate-modifying enzymes. CBMs affect the activity of these enzymes by modulating bonding and catalysis. To further characterize and study CBM-ligand binding interactions, neutron crystallographic studies of an engineered family 4-type CBM in complex with a branched xyloglucan ligand were conducted. The first neutron crystal structure of a CBM-ligand complex reported here shows numerous atomic details of hydrogen bonding and water-mediated interactions and reveals the charged state of key binding cleft amino acid side chains.
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Neutron Crystallographic Studies Reveal Hydrogen Bond and Water-Mediated Interactions between a Carbohydrate-Binding Module and Its Bound Carbohydrate Ligand.,Fisher SZ, von Schantz L, Hakansson M, Logan DT, Ohlin M Biochemistry. 2015 Oct 27;54(42):6435-8. doi: 10.1021/acs.biochem.5b01058. Epub, 2015 Oct 13. PMID:26451738<ref>PMID:26451738</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5dpn" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ohlin, M]]
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[[Category: Large Structures]]
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[[Category: Carbohydrate binding module hydrogen bond h/d exchanged]]
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[[Category: Rhodothermus marinus]]
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[[Category: Sugar binding protein]]
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[[Category: Ohlin M]]

Current revision

Engineered CBM X-2 L110F in complex with branched carbohydrate XXXG.

PDB ID 5dpn

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