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5fir
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of C. elegans XRN2 in complex with the XRN2-binding domain of PAXT-1== | |
| - | + | <StructureSection load='5fir' size='340' side='right'caption='[[5fir]], [[Resolution|resolution]] 2.84Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5fir]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FIR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FIR FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.836Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fir OCA], [https://pdbe.org/5fir PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fir RCSB], [https://www.ebi.ac.uk/pdbsum/5fir PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fir ProSAT]</span></td></tr> |
| - | [[Category: Grosshans | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: Katic | + | [https://www.uniprot.org/uniprot/XRN2_CAEEL XRN2_CAEEL] Possesses 5'->3' exoribonuclease activity. Plays a role in maintenance of steady-state concentration and turnover of microRNAs (miRNA) by degradation of mature miRNA. Partially redundant to xrn-1 in miRNA guide strand degradation. Implicated in differential regulation of mRNAs such as let-7 by controlling the accumulation of mature miRNA. Positively regulates molting of the pharyngeal cuticle.<ref>PMID:19734881</ref> <ref>PMID:21397849</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Caenorhabditis elegans]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Grosshans H]] | ||
| + | [[Category: Gut H]] | ||
| + | [[Category: Katic I]] | ||
| + | [[Category: Richter H]] | ||
Current revision
Crystal structure of C. elegans XRN2 in complex with the XRN2-binding domain of PAXT-1
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