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5fn6

From Proteopedia

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'''Unreleased structure'''
 
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The entry 5fn6 is ON HOLD
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==Crystal structure of human CD45 extracellular region, domains d1-d3==
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<StructureSection load='5fn6' size='340' side='right'caption='[[5fn6]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5fn6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FN6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FN6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fn6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fn6 OCA], [https://pdbe.org/5fn6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fn6 RCSB], [https://www.ebi.ac.uk/pdbsum/5fn6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fn6 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/PTPRC_HUMAN PTPRC_HUMAN] T-B+ severe combined immunodeficiency due to CD45 deficiency. The disease is caused by mutations affecting the gene represented in this entry. Disease susceptibility may be associated with variations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/PTPRC_HUMAN PTPRC_HUMAN] Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
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Authors: Chang, V.T., Fernandes, R.A., Ganzinger, K.A., Lee, S.F., Siebold, C., McColl, J., Jonsson, P., Palayret, M., Harlos, K., Coles, C.H., Jones, E.Y., Lui, Y., Huang, E., Gilbert, R.J.C., Klenerman, D., Aricescu, A.R., Davis, S.J.
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==See Also==
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*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
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Description: Crystal structure of human CD45 extracellular region, domains d1-d3
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__TOC__
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[[Category: Unreleased Structures]]
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</StructureSection>
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[[Category: Huang, E]]
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[[Category: Homo sapiens]]
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[[Category: Gilbert, R.J.C]]
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[[Category: Large Structures]]
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[[Category: Davis, S.J]]
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[[Category: Aricescu AR]]
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[[Category: Ganzinger, K.A]]
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[[Category: Chang VT]]
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[[Category: Lee, S.F]]
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[[Category: Coles CH]]
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[[Category: Aricescu, A.R]]
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[[Category: Davis SJ]]
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[[Category: Lui, Y]]
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[[Category: Fernandes RA]]
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[[Category: Harlos, K]]
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[[Category: Ganzinger KA]]
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[[Category: Coles, C.H]]
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[[Category: Gilbert RJC]]
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[[Category: Jones, E.Y]]
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[[Category: Harlos K]]
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[[Category: Fernandes, R.A]]
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[[Category: Huang E]]
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[[Category: Chang, V.T]]
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[[Category: Jones EY]]
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[[Category: Mccoll, J]]
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[[Category: Jonsson P]]
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[[Category: Klenerman, D]]
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[[Category: Klenerman D]]
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[[Category: Palayret, M]]
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[[Category: Lee SF]]
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[[Category: Jonsson, P]]
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[[Category: Lui Y]]
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[[Category: Siebold, C]]
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[[Category: McColl J]]
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[[Category: Palayret M]]
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[[Category: Siebold C]]

Current revision

Crystal structure of human CD45 extracellular region, domains d1-d3

PDB ID 5fn6

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