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5jif
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of mouse hepatitis virus strain DVIM Hemagglutinin-Esterase== | |
| + | <StructureSection load='5jif' size='340' side='right'caption='[[5jif]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5jif]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Murine_coronavirus_strain_DVIM Murine coronavirus strain DVIM]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JIF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JIF FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jif FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jif OCA], [https://pdbe.org/5jif PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jif RCSB], [https://www.ebi.ac.uk/pdbsum/5jif PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jif ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HEMA_CVMDV HEMA_CVMDV] Structural protein that makes short spikes at the surface of the virus. Contains receptor binding and receptor-destroying activities. Mediates de-O-acetylation of N-acetyl-9-O-acetylneuraminic acid, which is probably the receptor determinant recognized by the virus on the surface of erythrocytes and susceptible cells. This receptor-destroying activity is important for virus release as it probably helps preventing self-aggregation and ensures the efficient spread of the progeny virus from cell to cell. May serve as a secondary viral attachment protein for initiating infection, the spike protein being the major one. Seems to be a 'luxury' protein that is not absolutely necessary for virus infection in culture. However, its presence in the virus may alter its pathogenicity. May become a target for both the humoral and the cellular branches of the immune system. | ||
| - | + | ==See Also== | |
| - | + | *[[Hemagglutinin-esterase 3D structures|Hemagglutinin-esterase 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Murine coronavirus strain DVIM]] |
| - | [[Category: Feitsma | + | [[Category: Bakkers MJG]] |
| - | [[Category: | + | [[Category: Feitsma LJ]] |
| - | [[Category: Zeng | + | [[Category: Huizinga EG]] |
| + | [[Category: Zeng QH]] | ||
| + | [[Category: De Groot RJ]] | ||
Current revision
Crystal structure of mouse hepatitis virus strain DVIM Hemagglutinin-Esterase
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