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5lrm

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(New page: '''Unreleased structure''' The entry 5lrm is ON HOLD until Paper Publication Authors: Hinchliffe, P., Spencer, J. Description: Structure of di-zinc MCR-1 in P41212 space group [[Catego...)
Current revision (07:25, 1 May 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 5lrm is ON HOLD until Paper Publication
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==Structure of di-zinc MCR-1 in P41212 space group==
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<StructureSection load='5lrm' size='340' side='right'caption='[[5lrm]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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Authors: Hinchliffe, P., Spencer, J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5lrm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LRM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LRM FirstGlance]. <br>
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Description: Structure of di-zinc MCR-1 in P41212 space group
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Spencer, J]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lrm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lrm OCA], [https://pdbe.org/5lrm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lrm RCSB], [https://www.ebi.ac.uk/pdbsum/5lrm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lrm ProSAT]</span></td></tr>
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[[Category: Hinchliffe, P]]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MCR1_ECOLX MCR1_ECOLX] Probably catalyzes the addition of a phosphoethanolamine moiety to lipid A. Phosphoethanolamine modification of lipid A gives polymyxin resistance (PubMed:26603172).<ref>PMID:26603172</ref> Confers resistance to polymyxin-type antibiotics; expression of the Mcr-1 protein in E.coli increases colistin and polymyxin B minimal inhibitory concentration (MIC) from 0.5 mg/ml to 2.0 mg/ml. The pHNSHP45 plasmid can transfer efficiently (0.1 to 0.001) to other E.coli strains by conjugation and increases polymxin MIC by 8- to 16-fold; it may not require selective pressure to be maintained in the cell. When transformed into K.pneumoniae or P.aeruginosa it also increases polymxin MIC 8- to 16-fold. In a murine (BALB/c mice) thigh infection study using an mcr1-encoding plasmid isolated from a human patient, the plasmid confers in vivo protection against colistin (PubMed:26603172).<ref>PMID:26603172</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Escherichia coli]]
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[[Category: Large Structures]]
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[[Category: Hinchliffe P]]
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[[Category: Spencer J]]

Current revision

Structure of di-zinc MCR-1 in P41212 space group

PDB ID 5lrm

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