This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5v7z

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:28, 1 May 2024) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 5v7z is ON HOLD until Paper Publication
+
==SSNMR Structure of the Human RIP1/RIP3 Necrosome==
-
 
+
<StructureSection load='5v7z' size='340' side='right'caption='[[5v7z]]' scene=''>
-
Authors: Mompean, M., Li, W., Li, J., Laage, S., Siemer, A.B., Wu, H., McDermott, A.E.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[5v7z]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V7Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5V7Z FirstGlance]. <br>
-
Description: SSNMR Structure of the Human RIP1/RIP3 Necrosome
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solid-state NMR</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5v7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v7z OCA], [https://pdbe.org/5v7z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5v7z RCSB], [https://www.ebi.ac.uk/pdbsum/5v7z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5v7z ProSAT]</span></td></tr>
-
[[Category: Mompean, M]]
+
</table>
-
[[Category: Li, J]]
+
== Function ==
-
[[Category: Li, W]]
+
[https://www.uniprot.org/uniprot/RIPK3_HUMAN RIPK3_HUMAN] Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.<ref>PMID:19498109</ref> <ref>PMID:19524512</ref> <ref>PMID:19524513</ref> <ref>PMID:22265413</ref> <ref>PMID:22265414</ref> <ref>PMID:22421439</ref>
-
[[Category: Siemer, A.B]]
+
== References ==
-
[[Category: Laage, S]]
+
<references/>
-
[[Category: Mcdermott, A.E]]
+
__TOC__
-
[[Category: Wu, H]]
+
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Laage S]]
 +
[[Category: Li J]]
 +
[[Category: Li W]]
 +
[[Category: McDermott AE]]
 +
[[Category: Mompean M]]
 +
[[Category: Siemer AB]]
 +
[[Category: Wu H]]

Current revision

SSNMR Structure of the Human RIP1/RIP3 Necrosome

PDB ID 5v7z

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5v7z"
Personal tools