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5xme
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Solution structure of C-terminal domain of TRADD== | |
| - | + | <StructureSection load='5xme' size='340' side='right'caption='[[5xme]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5xme]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XME OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XME FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xme OCA], [https://pdbe.org/5xme PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xme RCSB], [https://www.ebi.ac.uk/pdbsum/5xme PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xme ProSAT]</span></td></tr> |
| - | [[Category: Lin | + | </table> |
| - | [[Category: Zhang | + | == Function == |
| + | [https://www.uniprot.org/uniprot/TRADD_HUMAN TRADD_HUMAN] The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Lin Z]] | ||
| + | [[Category: Zhang N]] | ||
Current revision
Solution structure of C-terminal domain of TRADD
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