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6nx4
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the C-terminal Helical Repeat Domain of Eukaryotic Elongation Factor 2 Kinase (eEF-2K)== | |
| - | + | <StructureSection load='6nx4' size='340' side='right'caption='[[6nx4]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6nx4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NX4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NX4 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nx4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nx4 OCA], [https://pdbe.org/6nx4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nx4 RCSB], [https://www.ebi.ac.uk/pdbsum/6nx4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nx4 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Ghose | + | == Function == |
| - | [[Category: Giles | + | [https://www.uniprot.org/uniprot/EF2K_HUMAN EF2K_HUMAN] Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced.<ref>PMID:14709557</ref> <ref>PMID:9144159</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Dalby KN]] | ||
| + | [[Category: Ghose R]] | ||
| + | [[Category: Giles DH]] | ||
| + | [[Category: Hajredini F]] | ||
| + | [[Category: Piserchio A]] | ||
| + | [[Category: Will N]] | ||
Current revision
Structure of the C-terminal Helical Repeat Domain of Eukaryotic Elongation Factor 2 Kinase (eEF-2K)
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Categories: Homo sapiens | Large Structures | Dalby KN | Ghose R | Giles DH | Hajredini F | Piserchio A | Will N
