6tn9
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6tn9 is ON HOLD Authors: Description: Category: Unreleased Structures) |
|||
| (4 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==X-RAY STRUCTURE OF MPS1 IN COMPLEX WITH COMPOUND 16== | |
| + | <StructureSection load='6tn9' size='340' side='right'caption='[[6tn9]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6tn9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TN9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TN9 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NN5:[4-[[6-(3,5-dimethyl-4-oxidanyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino]phenyl]-morpholin-4-yl-methanone'>NN5</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tn9 OCA], [https://pdbe.org/6tn9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tn9 RCSB], [https://www.ebi.ac.uk/pdbsum/6tn9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tn9 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bader B]] | ||
| + | [[Category: Boemer U]] | ||
| + | [[Category: Bohlmann R]] | ||
| + | [[Category: Brands M]] | ||
| + | [[Category: Briem H]] | ||
| + | [[Category: Eberspaecher U]] | ||
| + | [[Category: Fernandez-Montalvan A]] | ||
| + | [[Category: Holton SJ]] | ||
| + | [[Category: Klar U]] | ||
| + | [[Category: Koppitz M]] | ||
| + | [[Category: Kosemund D]] | ||
| + | [[Category: Marquardt T]] | ||
| + | [[Category: Nguyen D]] | ||
| + | [[Category: Nussbaum F]] | ||
| + | [[Category: Prechtl S]] | ||
| + | [[Category: Schirok H]] | ||
| + | [[Category: Schulze VK]] | ||
| + | [[Category: Siemeister G]] | ||
Current revision
X-RAY STRUCTURE OF MPS1 IN COMPLEX WITH COMPOUND 16
| |||||||||||
Categories: Homo sapiens | Large Structures | Bader B | Boemer U | Bohlmann R | Brands M | Briem H | Eberspaecher U | Fernandez-Montalvan A | Holton SJ | Klar U | Koppitz M | Kosemund D | Marquardt T | Nguyen D | Nussbaum F | Prechtl S | Schirok H | Schulze VK | Siemeister G
