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7ama
From Proteopedia
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==IL-17A in complex with small molecule modulators== | ==IL-17A in complex with small molecule modulators== | ||
| - | <StructureSection load='7ama' size='340' side='right'caption='[[7ama]]' scene=''> | + | <StructureSection load='7ama' size='340' side='right'caption='[[7ama]], [[Resolution|resolution]] 2.48Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AMA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7AMA FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7ama]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AMA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7AMA FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ama FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ama OCA], [https://pdbe.org/7ama PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ama RCSB], [https://www.ebi.ac.uk/pdbsum/7ama PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ama ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.48Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RMK:~{N}-[(2~{S})-1,1-dicyclopropyl-3-[[4-(3,5-dimethyl-1~{H}-pyrazol-4-yl)phenyl]amino]-3-oxidanylidene-propan-2-yl]-2-propan-2-yl-pyrazole-3-carboxamide'>RMK</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ama FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ama OCA], [https://pdbe.org/7ama PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ama RCSB], [https://www.ebi.ac.uk/pdbsum/7ama PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ama ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/IL17_HUMAN IL17_HUMAN] Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Interleukin 3D structures|Interleukin 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Andrews MD]] | [[Category: Andrews MD]] | ||
Current revision
IL-17A in complex with small molecule modulators
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Categories: Homo sapiens | Large Structures | Andrews MD | Dack KN | Hakansson M | Kimbung R | Lambert M | Logan D | Walse UB | De Groot MJ
