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7bgj
From Proteopedia
(Difference between revisions)
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==C. thermophilum Pyruvate Dehydrogenase Complex Core== | ==C. thermophilum Pyruvate Dehydrogenase Complex Core== | ||
| - | <StructureSection load='7bgj' size='340' side='right'caption='[[7bgj]]' scene=''> | + | <StructureSection load='7bgj' size='340' side='right'caption='[[7bgj]], [[Resolution|resolution]] 6.90Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BGJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BGJ FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7bgj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum_var._thermophilum_DSM_1495 Chaetomium thermophilum var. thermophilum DSM 1495]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BGJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BGJ FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bgj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bgj OCA], [https://pdbe.org/7bgj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bgj RCSB], [https://www.ebi.ac.uk/pdbsum/7bgj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bgj ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.9Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bgj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bgj OCA], [https://pdbe.org/7bgj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bgj RCSB], [https://www.ebi.ac.uk/pdbsum/7bgj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bgj ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ODP2_CHATD ODP2_CHATD] The 10-megadalton pyruvate dehydrogenase complex contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) and catalyzes the overall oxidative decarboxylation of pyruvate to form acetyl-CoA and CO(2) (PubMed:33567276, PubMed:34836937, PubMed:35093201). Within the complex, pyruvate and thiamine pyrophosphate (TPP or vitamin B1) are bound by pyruvate dehydrogenase E1 subunits alpha and beta and pyruvate is decarboxylated leading to the 2-carbon hydrohyethyl bound to TPP. The E2 component contains covalently-bound lipoyl cofactors and transfers the hydroxyethyl group from TPP to an oxidized form of covalently bound lipoamide, and the resulting acetyl group is then transferred to free coenzyme A to form acetyl-CoA and reduced dihydrolipoamide-E2. Finally, the flavoprotein dihydrolipoamide dehydrogenase (E3) re-oxidizes the lipoyl group of dihydrolipoamide-E2 to form lipoamide-E2 and NADH. A fourth subunit, E3BP, is responsible for tethering E3 in proximity to the core, forming the entire metabolon (Probable).<ref>PMID:33567276</ref> <ref>PMID:34836937</ref> <ref>PMID:35093201</ref> <ref>PMID:33567276</ref> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Pyruvate dehydrogenase 3D structures|Pyruvate dehydrogenase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Chaetomium thermophilum var. thermophilum DSM 1495]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Kastritis PL]] | [[Category: Kastritis PL]] | ||
[[Category: Tueting C]] | [[Category: Tueting C]] | ||
Current revision
C. thermophilum Pyruvate Dehydrogenase Complex Core
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