This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


7dac

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:49, 1 May 2024) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 7dac is ON HOLD until Paper Publication
+
==Human RIPK3 amyloid fibril revealed by solid-state NMR==
 +
<StructureSection load='7dac' size='340' side='right'caption='[[7dac]]' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[7dac]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DAC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DAC FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solid-state NMR</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dac OCA], [https://pdbe.org/7dac PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dac RCSB], [https://www.ebi.ac.uk/pdbsum/7dac PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dac ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/RIPK3_HUMAN RIPK3_HUMAN] Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.<ref>PMID:19498109</ref> <ref>PMID:19524512</ref> <ref>PMID:19524513</ref> <ref>PMID:22265413</ref> <ref>PMID:22265414</ref> <ref>PMID:22421439</ref>
-
Authors:
+
==See Also==
-
 
+
*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
-
Description:
+
== References ==
-
[[Category: Unreleased Structures]]
+
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Dong XQ]]
 +
[[Category: Hu H]]
 +
[[Category: Li B]]
 +
[[Category: Liu J]]
 +
[[Category: Lu JX]]
 +
[[Category: Wang HY]]
 +
[[Category: Wang J]]
 +
[[Category: Wu XL]]
 +
[[Category: Zhang J]]

Current revision

Human RIPK3 amyloid fibril revealed by solid-state NMR

PDB ID 7dac

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/7dac"
Personal tools