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7dac

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Current revision (07:49, 1 May 2024) (edit) (undo)
 
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<StructureSection load='7dac' size='340' side='right'caption='[[7dac]]' scene=''>
<StructureSection load='7dac' size='340' side='right'caption='[[7dac]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DAC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DAC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7dac]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DAC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DAC FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dac OCA], [https://pdbe.org/7dac PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dac RCSB], [https://www.ebi.ac.uk/pdbsum/7dac PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dac ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solid-state NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dac OCA], [https://pdbe.org/7dac PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dac RCSB], [https://www.ebi.ac.uk/pdbsum/7dac PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dac ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RIPK3_HUMAN RIPK3_HUMAN] Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.<ref>PMID:19498109</ref> <ref>PMID:19524512</ref> <ref>PMID:19524513</ref> <ref>PMID:22265413</ref> <ref>PMID:22265414</ref> <ref>PMID:22421439</ref>
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==See Also==
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*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Dong XQ]]
[[Category: Dong XQ]]

Current revision

Human RIPK3 amyloid fibril revealed by solid-state NMR

PDB ID 7dac

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