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7jk8
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==EmrE S64V mutant bound to tetra(4-fluorophenyl)phosphonium at pH 5.8== | |
| - | + | <StructureSection load='7jk8' size='340' side='right'caption='[[7jk8]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7jk8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JK8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JK8 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solid-state NMR</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=VCJ:tetrakis(4-fluorophenyl)phosphanium'>VCJ</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jk8 OCA], [https://pdbe.org/7jk8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jk8 RCSB], [https://www.ebi.ac.uk/pdbsum/7jk8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jk8 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/EMRE_ECOLI EMRE_ECOLI] Multidrug transporter that expels positively charged hydrophobic drugs across the inner membrane of E.coli., thereby conferring resistance to a wide range of toxic compounds. The drug efflux is coupled to an influx of protons. Is involved in the resistance of E.coli cells to methyl viologen, ethidium bromide and acriflavine. Is also able to transport tetraphenylphosphonium (TPP(+)) and benzalkonium.<ref>PMID:7896833</ref> <ref>PMID:10681497</ref> <ref>PMID:15371426</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Escherichia coli]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Davis Jr JH]] | ||
| + | [[Category: Henzler-Wildman KA]] | ||
| + | [[Category: Hisao G]] | ||
| + | [[Category: Hong M]] | ||
| + | [[Category: Mandala VS]] | ||
| + | [[Category: Salter EA]] | ||
| + | [[Category: Shcherbakov AA]] | ||
| + | [[Category: Soltani M]] | ||
| + | [[Category: Thomas NE]] | ||
Current revision
EmrE S64V mutant bound to tetra(4-fluorophenyl)phosphonium at pH 5.8
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