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7p6r
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the FimH-binding decoy module of human glycoprotein 2 (GP2) (crystal form I)== | |
| - | + | <StructureSection load='7p6r' size='340' side='right'caption='[[7p6r]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7p6r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7P6R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7P6R FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7p6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7p6r OCA], [https://pdbe.org/7p6r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7p6r RCSB], [https://www.ebi.ac.uk/pdbsum/7p6r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7p6r ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GP2_HUMAN GP2_HUMAN] Functions as an intestinal M-cell transcytotic receptor specific of type-I-piliated bacteria that participates in the mucosal immune response toward these bacteria. At the apical membrane of M-cells it binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typhimurium, from the lumen of the intestine and delivers them, through M-cells, to the underlying organized lymphoid follicles where they are captured by antigen-presenting dendritic cells to elicit a mucosal immune response.<ref>PMID:19907495</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Jovine L]] | ||
| + | [[Category: Jumper J]] | ||
| + | [[Category: Stsiapanava A]] | ||
| + | [[Category: Tunyasuvunakool K]] | ||
| + | [[Category: De Sanctis D]] | ||
Current revision
Crystal structure of the FimH-binding decoy module of human glycoprotein 2 (GP2) (crystal form I)
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