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7zn6
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7zn6 is ON HOLD Authors: Kosinas, C., Dimarogona, M., Zerva, A., Topakas, E. Description: Crystal structure of laccase-like multicopper oxidase (LM...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of laccase-like multicopper oxidase (LMCO) from Thermothelomyces thermophilus== | |
| - | + | <StructureSection load='7zn6' size='340' side='right'caption='[[7zn6]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7zn6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermothelomyces_thermophilus_ATCC_42464 Thermothelomyces thermophilus ATCC 42464]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZN6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZN6 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=OXY:OXYGEN+MOLECULE'>OXY</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zn6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zn6 OCA], [https://pdbe.org/7zn6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zn6 RCSB], [https://www.ebi.ac.uk/pdbsum/7zn6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zn6 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/LMCO1_MYCTT LMCO1_MYCTT] Yellow laccase-like multicopper oxidase that is able to oxidize a variety of phenolic compounds including standard laccase substrates such as 2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) and 2,6-dimethoxyphenol (2,6-DMP) (PubMed:30529567). Can be used for the bioconversion of 2',3,4-trihy-droxychalcone to 3',4'-dihydroxy-aurone, a bioactive aurone recently shown to possess inhibitory activity against several isoforms of the histone deacetylase complex (HDAC) (PubMed:30529567).<ref>PMID:30529567</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Thermothelomyces thermophilus ATCC 42464]] | ||
| + | [[Category: Dimarogona M]] | ||
| + | [[Category: Kosinas C]] | ||
| + | [[Category: Topakas E]] | ||
| + | [[Category: Zerva A]] | ||
Current revision
Crystal structure of laccase-like multicopper oxidase (LMCO) from Thermothelomyces thermophilus
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