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8a0u
From Proteopedia
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==Crystal structure of TEAD3 in complex with CPD4== | ==Crystal structure of TEAD3 in complex with CPD4== | ||
| - | <StructureSection load='8a0u' size='340' side='right'caption='[[8a0u]]' scene=''> | + | <StructureSection load='8a0u' size='340' side='right'caption='[[8a0u]], [[Resolution|resolution]] 2.90Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8A0U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8A0U FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[8a0u]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8A0U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8A0U FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a0u OCA], [https://pdbe.org/8a0u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a0u RCSB], [https://www.ebi.ac.uk/pdbsum/8a0u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a0u ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.895Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KMU:2-[(2~{S})-2-(aminomethyl)-5-chloranyl-2-phenyl-3~{H}-1-benzofuran-4-yl]benzamide'>KMU</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a0u OCA], [https://pdbe.org/8a0u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a0u RCSB], [https://www.ebi.ac.uk/pdbsum/8a0u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a0u ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TEAD3_MOUSE TEAD3_MOUSE] Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction (By similarity). | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Kallen J]] | [[Category: Kallen J]] | ||
[[Category: Scheufler C]] | [[Category: Scheufler C]] | ||
Current revision
Crystal structure of TEAD3 in complex with CPD4
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