This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1qk6

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:21, 1 May 2024) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1qk6.png|left|200px]]
 
-
{{STRUCTURE_1qk6| PDB=1qk6 | SCENE= }}
+
==Solution structure of huwentoxin-I by NMR==
-
 
+
<StructureSection load='1qk6' size='340' side='right'caption='[[1qk6]]' scene=''>
-
===SOLUTION STRUCTURE OF HUWENTOXIN-I BY NMR===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[1qk6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cyriopagopus_schmidti Cyriopagopus schmidti]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QK6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QK6 FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_9263120}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
 
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qk6 OCA], [https://pdbe.org/1qk6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qk6 RCSB], [https://www.ebi.ac.uk/pdbsum/1qk6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qk6 ProSAT]</span></td></tr>
-
==About this Structure==
+
</table>
-
[[1qk6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Haplopelma_schmidti Haplopelma schmidti]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QK6 OCA].
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/TXH1_CYRSC TXH1_CYRSC] Lethal toxin with multiple biological activities. Inhibits voltage-gated TTX-sensitive sodium channels in DRG neurons (IC(50)=55 nM) and also shows activity when directly tested on Nav1.7/SCN9A (IC(50)=25.1-630 nM) (PubMed:17451655, PubMed:21731778, PubMed:31234412). Inhibits N-type calcium channels (Cav2.2/CACNA1B (IC(50)=100 nM)) (PubMed:11024489, PubMed:17451655). Also blocks neuromuscular transmission (PubMed:8212049, PubMed:9028007, PubMed:10736477). In vivo, intrathecal injected toxin shows analgesic activity in the rat formalin-induced pain model, without induction of motor dysfunction in rats.<ref>PMID:15581678</ref>
-
==Reference==
+
== References ==
-
<ref group="xtra">PMID:009263120</ref><references group="xtra"/>
+
<references/>
-
[[Category: Haplopelma schmidti]]
+
__TOC__
-
[[Category: Ding, J.]]
+
</StructureSection>
-
[[Category: Gu, X.]]
+
[[Category: Cyriopagopus schmidti]]
-
[[Category: Liang, S.]]
+
[[Category: Large Structures]]
-
[[Category: Liu, X.]]
+
[[Category: Ding J]]
-
[[Category: Qu, Y.]]
+
[[Category: Gu X]]
-
[[Category: Zhang, R.]]
+
[[Category: Liang S]]
-
[[Category: Cystine knot]]
+
[[Category: Liu X]]
-
[[Category: Huwentoxin-i]]
+
[[Category: Qu Y]]
-
[[Category: Spider]]
+
[[Category: Zhang R]]
-
[[Category: Toxin]]
+

Current revision

Solution structure of huwentoxin-I by NMR

PDB ID 1qk6

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1qk6"
Personal tools